BACKGROUND: There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. METHODS: All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. RESULTS: 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6-20) in individuals 80-89 years of age (p < .001). Cyst prevalence was significantly higher in patients who underwent CT for malignancy (p = .038) but this difference was no longer significant in multivariate analysis. The odds of a cyst being present increased by 1.05 (95% CI 1.02-1.09) for each increasing year of age (p = .002). Approximately a quarter of the patients with cysts died within 1 year after CT from non pancreas-related disease. The estimated standardized age-adjusted cyst prevalence is 2194 per 100,000 people. CONCLUSIONS: The likelihood of having a pancreatic cyst correlates with increasing age, not with the presence of extra-pancreatic malignancies. The estimated prevalence of CT-detectable asymptomatic pancreatic cysts in the general population is 2.2%.
BACKGROUND: There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. METHODS: All the individuals who undergo CT at the San Marino State Hospital are residents of the Republic of San Marino; their demographic distribution is available and precise. CT scans carried out over 1 year at the State Hospital were reviewed for asymptomatic pancreatic cysts. RESULTS: 1061 relevant CT scans were carried out on 814 patients; 762 individuals were eligible for the study and 650 patients underwent contrast-enhanced CT. Thirty-five patients had at least one cyst at contrast-enhanced CT (5.4%). The prevalence of cysts increased with increasing age up to 13.4% (95% CI 6.6-20) in individuals 80-89 years of age (p < .001). Cyst prevalence was significantly higher in patients who underwent CT for malignancy (p = .038) but this difference was no longer significant in multivariate analysis. The odds of a cyst being present increased by 1.05 (95% CI 1.02-1.09) for each increasing year of age (p = .002). Approximately a quarter of the patients with cysts died within 1 year after CT from non pancreas-related disease. The estimated standardized age-adjusted cyst prevalence is 2194 per 100,000 people. CONCLUSIONS: The likelihood of having a pancreatic cyst correlates with increasing age, not with the presence of extra-pancreatic malignancies. The estimated prevalence of CT-detectable asymptomatic pancreatic cysts in the general population is 2.2%.
Authors: Pallavi Pandey; Ankur Pandey; Yan Luo; Mounes Aliyari Ghasabeh; Pegah Khoshpouri; Sanaz Ameli; Anne Marie O'Broin-Lennon; Marcia Canto; Ralph H Hruban; Michael S Goggins; Christopher Wolfgang; Ihab R Kamel Journal: Radiology Date: 2019-07-16 Impact factor: 11.105
Authors: Alex B Blair; Ross M Beckman; Joseph R Habib; James F Griffin; Kelly Lafaro; Richard A Burkhart; William Burns; Matthew J Weiss; John L Cameron; Christopher L Wolfgang; Jin He Journal: HPB (Oxford) Date: 2021-09-23 Impact factor: 3.842
Authors: Giulia Zerboni; Gabriele Capurso; Marco Di Pietropaolo; Francesco Carbonetti; Elsa Iannicelli; Massimo Marignani; Gianfranco Delle Fave Journal: United European Gastroenterol J Date: 2017-02-09 Impact factor: 4.623
Authors: Lorraine Abel; Jakob Wasserthal; Thomas Weikert; Alexander W Sauter; Ivan Nesic; Marko Obradovic; Shan Yang; Sebastian Manneck; Carl Glessgen; Johanna M Ospel; Bram Stieltjes; Daniel T Boll; Björn Friebe Journal: Diagnostics (Basel) Date: 2021-05-19