Literature DB >> 26027536

Drug discovery for the developing world: progress at the Novartis Institute for Tropical Diseases.

Catherine L Jones1, Bryan K S Yeung2, Ujjini Manjunatha2, Pei-Yong Shi2, Christophe Bodenreider2, Thierry T Diagana2.   

Abstract

Mesh：

Year:  2015        PMID： 26027536     DOI： 10.1038/nrd4001-c1

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  21 in total

Review 1.  Advances in the development of new tuberculosis drugs and treatment regimens.

Authors:  Alimuddin Zumla; Payam Nahid; Stewart T Cole
Journal:  Nat Rev Drug Discov       Date:  2013-05       Impact factor: 84.694

2.  Ligand-bound structures of the dengue virus protease reveal the active conformation.

Authors:  Christian G Noble; Cheah Chen Seh; Alexander T Chao; Pei Yong Shi
Journal:  J Virol       Date:  2011-10-26       Impact factor: 5.103

3.  Spiroindolones, a potent compound class for the treatment of malaria.

Authors:  Matthias Rottmann; Case McNamara; Bryan K S Yeung; Marcus C S Lee; Bin Zou; Bruce Russell; Patrick Seitz; David M Plouffe; Neekesh V Dharia; Jocelyn Tan; Steven B Cohen; Kathryn R Spencer; Gonzalo E González-Páez; Suresh B Lakshminarayana; Anne Goh; Rossarin Suwanarusk; Timothy Jegla; Esther K Schmitt; Hans-Peter Beck; Reto Brun; Francois Nosten; Laurent Renia; Veronique Dartois; Thomas H Keller; David A Fidock; Elizabeth A Winzeler; Thierry T Diagana
Journal:  Science       Date:  2010-09-03       Impact factor: 47.728

4.  Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

Authors:  Fumiaki Yokokawa; Gang Wang; Wai Ling Chan; Shi Hua Ang; Josephine Wong; Ida Ma; Srinivasa P S Rao; Ujjini Manjunatha; Suresh B Lakshminarayana; Maxime Herve; Cyrille Kounde; Bee Huat Tan; Pamela Thayalan; Seow Hwee Ng; Mahesh Nanjundappa; Sindhu Ravindran; Peck Gee; Maria Tan; Liu Wei; Anne Goh; Pei-Yu Chen; Kok Sin Lee; Chen Zhong; Trixie Wagner; Ina Dix; Arnab K Chatterjee; Kevin Pethe; Kelli Kuhen; Richard Glynne; Paul Smith; Pablo Bifani; Jan Jiricek
Journal:  ACS Med Chem Lett       Date:  2013-04-01       Impact factor: 4.345

5.  Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.

Authors:  Srinivasa P S Rao; Suresh B Lakshminarayana; Ravinder R Kondreddi; Maxime Herve; Luis R Camacho; Pablo Bifani; Sarath K Kalapala; Jan Jiricek; Ng L Ma; Bee H Tan; Seow H Ng; Mahesh Nanjundappa; Sindhu Ravindran; Peck G Seah; Pamela Thayalan; Siao H Lim; Boon H Lee; Anne Goh; Whitney S Barnes; Zhong Chen; Kerstin Gagaring; Arnab K Chatterjee; Kevin Pethe; Kelli Kuhen; John Walker; Gu Feng; Sreehari Babu; Lijun Zhang; Francesca Blasco; David Beer; Margaret Weaver; Veronique Dartois; Richard Glynne; Thomas Dick; Paul W Smith; Thierry T Diagana; Ujjini H Manjunatha
Journal:  Sci Transl Med       Date:  2013-12-04       Impact factor: 17.956

6.  Spiroindolone KAE609 for falciparum and vivax malaria.

Authors:  Nicholas J White; Sasithon Pukrittayakamee; Aung Pyae Phyo; Ronnatrai Rueangweerayut; François Nosten; Podjanee Jittamala; Atthanee Jeeyapant; Jay Prakash Jain; Gilbert Lefèvre; Ruobing Li; Baldur Magnusson; Thierry T Diagana; F Joel Leong
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

7.  Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.

Authors:  Natalie J Spillman; Richard J W Allen; Case W McNamara; Bryan K S Yeung; Elizabeth A Winzeler; Thierry T Diagana; Kiaran Kirk
Journal:  Cell Host Microbe       Date:  2013-02-13       Impact factor: 21.023

8.  Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.

Authors:  Laurent Dembele; Audrey Gego; Anne-Marie Zeeman; Jean-François Franetich; Olivier Silvie; Armelle Rametti; Roger Le Grand; Nathalie Dereuddre-Bosquet; Robert Sauerwein; Geert-Jan van Gemert; Jean-Christophe Vaillant; Alan W Thomas; Georges Snounou; Clemens H M Kocken; Dominique Mazier
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

9.  A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

Authors:  Kevin Pethe; Patricia C Sequeira; Sanjay Agarwalla; Kyu Rhee; Kelli Kuhen; Wai Yee Phong; Viral Patel; David Beer; John R Walker; Jeyaraj Duraiswamy; Jan Jiricek; Thomas H Keller; Arnab Chatterjee; Mai Ping Tan; Manjunatha Ujjini; Srinivasa P S Rao; Luis Camacho; Pablo Bifani; Puiying A Mak; Ida Ma; S Whitney Barnes; Zhong Chen; David Plouffe; Pamela Thayalan; Seow Hwee Ng; Melvin Au; Boon Heng Lee; Bee Huat Tan; Sindhu Ravindran; Mahesh Nanjundappa; Xiuhua Lin; Anne Goh; Suresh B Lakshminarayana; Carolyn Shoen; Michael Cynamon; Barry Kreiswirth; Veronique Dartois; Eric C Peters; Richard Glynne; Sydney Brenner; Thomas Dick
Journal:  Nat Commun       Date:  2010-08-24       Impact factor: 14.919

10.  Targeting Plasmodium PI(4)K to eliminate malaria.

Authors:  Case W McNamara; Marcus Cs Lee; Chek Shik Lim; Siau Hoi Lim; Jason Roland; Oliver Simon; Bryan Ks Yeung; Arnab K Chatterjee; Susan L McCormack; Micah J Manary; Anne-Marie Zeeman; Koen J Dechering; Tr Santha Kumar; Philipp P Henrich; Kerstin Gagaring; Maureen Ibanez; Nobutaka Kato; Kelli L Kuhen; Christoph Fischli; Advait Nagle; Matthias Rottmann; David M Plouffe; Badry Bursulaya; Stephan Meister; Lucia Rameh; Joerg Trappe; Dorothea Haasen; Martijn Timmerman; Robert W Sauerwein; Rossarin Suwanarusk; Bruce Russell; Laurent Renia; Francois Nosten; David C Tully; Clemens Hm Kocken; Richard J Glynne; Christophe Bodenreider; David A Fidock; Thierry T Diagana; Elizabeth A Winzeler
Journal:  Nature       Date:  2013-11-27       Impact factor: 49.962
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  1 in total

Review 1.  Approved Antiviral Drugs over the Past 50 Years.

Authors:  Erik De Clercq; Guangdi Li
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132
  1 in total

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