Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats.

Bisphenol A (BPA) is a fairly ubiquitous compound which has a great concern to human health. The current study was designed to (1) Assess the adverse effect of oral administration of BPA on liver of male rats and (2) Evaluate the role of thymoquinone (TQ), the major bioactive ingredient in the oil of Nigella sativa seed, in alleviating the possible detrimental effects of BPA on the liver. Rats were divided into control group administered olive oil, BPA group administered 10 mg BPA kg(-1) day(-1), TQ group administered 10 mg TQ kg(-1) day(-1) and BPA-TQ group administered the same previous doses of both BPA and TQ. After 24 h of the last dose, rats were decapitated and blood and liver were collected to determine some oxidative stress and biochemical parameters. Bisphenol A elicited a significant elevation in lipid peroxidation concomitant with depletion of antioxidant defense system in hepatic tissue. It also induced liver dysfunction as indicated by altered liver function markers and biochemical parameters. The administration of TQ attenuated the BPA-induced oxidative stress, alleviated the antioxidative system and improved to a large extent the liver functioning. This data clearly indicates that TQ has the potential to be a protective agent against oxidative stress and liver injury.