Literature DB >> 26026993

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

Herman Autrup1, Frank A Barile2, Bas J Blaauboer3, Gisela H Degen4, Wolfgang Dekant5, Daniel Dietrich6, Jose L Domingo7, Gio Batta Gori8, Helmuth Greim9, Jan G Hengstler4, Sam Kacew10, Hans Marquardt11, Olavi Pelkonen12, Kai Savolainen13, Nico P Vermeulen14.   

Abstract

The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.
© The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Keywords:  endocrine disruptors; endocrine toxicology; regulatory/policy; risk assessment

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Year:  2015        PMID： 26026993     DOI： 10.1093/toxsci/kfv082

Source DB:  PubMed          Journal:  Toxicol Sci        ISSN： 1096-0929            Impact factor:   4.849


  5 in total

Review 1.  Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals.

Authors:  Leonardo Trasande; Laura N Vandenberg; Jean-Pierre Bourguignon; John Peterson Myers; Remy Slama; Frederick Vom Saal; Robert Thomas Zoeller
Journal:  J Epidemiol Community Health       Date:  2016-07-13       Impact factor: 3.710

2.  Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.

Authors:  U Gundert-Remy; H Barth; A Bürkle; G H Degen; R Landsiedel
Journal:  Arch Toxicol       Date:  2015-08-28       Impact factor: 5.153

3.  Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.

Authors:  Roland Solecki; Andreas Kortenkamp; Åke Bergman; Ibrahim Chahoud; Gisela H Degen; Daniel Dietrich; Helmut Greim; Helen Håkansson; Ulla Hass; Trine Husoy; Miriam Jacobs; Susan Jobling; Alberto Mantovani; Philip Marx-Stoelting; Aldert Piersma; Vera Ritz; Remy Slama; Ralf Stahlmann; Martin van den Berg; R Thomas Zoeller; Alan R Boobis
Journal:  Arch Toxicol       Date:  2016-10-06       Impact factor: 5.153

4.  Does GLP enhance the quality of toxicological evidence for regulatory decisions?

Authors:  Christopher J Borgert; Richard A Becker; Betsy D Carlton; Mark Hanson; Patricia L Kwiatkowski; Mary Sue Marty; Lynn S McCarty; Terry F Quill; Keith Solomon; Glen Van Der Kraak; Raphael J Witorsch; Kun Don Yi
Journal:  Toxicol Sci       Date:  2016-05-05       Impact factor: 4.849

5.  Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

Authors:  Herman Autrup; Frank A Barile; Sir Colin Berry; Bas J Blaauboer; Alan Boobis; Herrmann Bolt; Christopher J Borgert; Wolfgang Dekant; Daniel Dietrich; Jose L Domingo; Gio Batta Gori; Helmut Greim; Jan Hengstler; Sam Kacew; Hans Marquardt; Olavi Pelkonen; Kai Savolainen; Pat Heslop-Harrison; Nico P Vermeulen
Journal:  Arch Toxicol       Date:  2020-06-08       Impact factor: 5.153
  5 in total

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