R Villegas1, Y Takata2, H Murff2, W J Blot3. 1. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: raquel.villegas@vanderbilt.edu. 2. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. 3. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; International Epidemiology Institute, Rockville, MD, USA.
Abstract
BACKGROUND: We examined associations between fish and n-3 LCFA and mortality in a prospective study with a large proportion of blacks with low socio-economic status. METHODS AND RESULTS: We observed 6914 deaths among 77,604 participants with dietary data (follow-up time 5.5 years). Of these, 77,100 participants had available time-to-event data. We investigated associations between mortality with fish and n-3 LCFA intake, adjusting for age, race, sex, kcal/day, body mass index (BMI), smoking, alcohol consumption, physical activity, income, education, chronic disease, insurance coverage, and meat intake. Intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower mortality among all participants. Analysis of trends in overall mortality by quintiles of intake showed that intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower risk of total mortality among all participants. When participants with chronic disease were excluded, the observed association remained only between intakes of baked/grilled fish, while fried fish was associated with lower risk of mortality in participants with prevalent chronic disease. The association between n-3 LCFA intake and lower risk of mortality was significant among those with diabetes at baseline. There was an inverse association of mortality with fried fish intake in men, but not women. Total fish and baked/grilled fish intakes were associated with lower mortality among blacks while fried fish intake was associated with lower mortality among whites. Effect modifications were not statistically significant. CONCLUSION: Our findings suggest a modest benefit of fish consumption on mortality.
BACKGROUND: We examined associations between fish and n-3 LCFA and mortality in a prospective study with a large proportion of blacks with low socio-economic status. METHODS AND RESULTS: We observed 6914 deaths among 77,604 participants with dietary data (follow-up time 5.5 years). Of these, 77,100 participants had available time-to-event data. We investigated associations between mortality with fish and n-3 LCFA intake, adjusting for age, race, sex, kcal/day, body mass index (BMI), smoking, alcohol consumption, physical activity, income, education, chronic disease, insurance coverage, and meat intake. Intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower mortality among all participants. Analysis of trends in overall mortality by quintiles of intake showed that intakes of fried fish, baked/grilled fish and total fish, but not tuna, were associated with lower risk of total mortality among all participants. When participants with chronic disease were excluded, the observed association remained only between intakes of baked/grilled fish, while fried fish was associated with lower risk of mortality in participants with prevalent chronic disease. The association between n-3 LCFA intake and lower risk of mortality was significant among those with diabetes at baseline. There was an inverse association of mortality with fried fish intake in men, but not women. Total fish and baked/grilled fish intakes were associated with lower mortality among blacks while fried fish intake was associated with lower mortality among whites. Effect modifications were not statistically significant. CONCLUSION: Our findings suggest a modest benefit of fish consumption on mortality.
Authors: Man Ping Wang; G Neil Thomas; Sai Yin Ho; Hak Kan Lai; Kwok Hang Mak; Tai Hing Lam Journal: Ann Epidemiol Date: 2010-12-15 Impact factor: 3.797
Authors: Lisa B Signorello; Margaret K Hargreaves; Mark D Steinwandel; Wei Zheng; Qiuyin Cai; David G Schlundt; Maciej S Buchowski; Carolyne W Arnold; Joseph K McLaughlin; William J Blot Journal: J Natl Med Assoc Date: 2005-07 Impact factor: 1.798
Authors: Timothy J Key; Paul N Appleby; Elizabeth A Spencer; Ruth C Travis; Andrew W Roddam; Naomi E Allen Journal: Am J Clin Nutr Date: 2009-03-18 Impact factor: 7.045
Authors: Evangelos C Rizos; Evangelia E Ntzani; Eftychia Bika; Michael S Kostapanos; Moses S Elisaf Journal: JAMA Date: 2012-09-12 Impact factor: 56.272
Authors: Lisa B Signorello; Heather M Munro; Maciej S Buchowski; David G Schlundt; Sarah S Cohen; Margaret K Hargreaves; William J Blot Journal: Am J Epidemiol Date: 2009-05-18 Impact factor: 4.897
Authors: Lisa B Signorello; Maciej S Buchowski; Qiuyin Cai; Heather M Munro; Margaret K Hargreaves; William J Blot Journal: Am J Epidemiol Date: 2010-01-08 Impact factor: 4.897
Authors: Fatin Hanani Mazri; Zahara Abdul Manaf; Suzana Shahar; Arimi Fitri Mat Ludin Journal: Int J Environ Res Public Health Date: 2019-12-20 Impact factor: 3.390