M A Allison1, M H Criqui2, A S Maisel2, L B Daniels2, C K Roberts3, J F Polak4, M Cushman5. 1. Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: mallison@ucsd.edu. 2. Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA. 3. Pritikin Research Foundation Los Angeles, Los Angeles, CA, USA. 4. Department of Radiology, Tufts Medical Center, Boston, MA, USA. 5. Department of Pathology, University of Vermont, Burlington, VT, USA.
Abstract
BACKGROUND AND AIMS: To investigate the associations between selected adipokines and the N-terminal prohormone of B-type natriuretic peptide (NT-proBNP). METHODS AND RESULTS: As many as 1489 individuals enrolled in the Multi-Ethnic Study of Atherosclerosis were evaluated at 4 clinic visits about every 2 years. The evaluation included fasting venous blood, which was analyzed for NT-proBNP (at visits 1 and 3) and the adipokines adiponectin and leptin (at visits 2 and 3). The mean age was 64.8 ± 9.6 years and 48% were female. After multivariable adjustment, a 1-SD increment in adiponectin was associated with a 14 pg/ml higher NT-proBNP level (p < 0.01), while, compared to the 1st quartile of adiponectin, the 2nd, 3rd and 4th quartiles had 28, 45 and 67% higher NT-proBNP levels (p < 0.01 for all). For changes in NT-proBNP over the follow-up period, and after multivariable adjustment including baseline NT-proBNP, a 1-SD increment in adiponectin was associated with a 25 pg/ml absolute increase in NT-proBNP (p < 0.01), while those in the 2nd, 3rd and 4th quartiles of adiponectin were associated with increases of 5, 28 and 65 pg/ml (p = 0.74, 0.09 and <0.01, respectively). There was a significant interaction between adiponectin and sex for visit 3 NT-proBNP (p-interaction < 0.01), with significantly stronger associations in men. Leptin was not associated with NT-proBNP. CONCLUSION: Higher adiponectin, but not leptin, is significantly associated with higher levels of NT-proBNP, as well as with greater longitudinal increases in NT-proBNP. The associations were stronger in men.
BACKGROUND AND AIMS: To investigate the associations between selected adipokines and the N-terminal prohormone of B-type natriuretic peptide (NT-proBNP). METHODS AND RESULTS: As many as 1489 individuals enrolled in the Multi-Ethnic Study of Atherosclerosis were evaluated at 4 clinic visits about every 2 years. The evaluation included fasting venous blood, which was analyzed for NT-proBNP (at visits 1 and 3) and the adipokines adiponectin and leptin (at visits 2 and 3). The mean age was 64.8 ± 9.6 years and 48% were female. After multivariable adjustment, a 1-SD increment in adiponectin was associated with a 14 pg/ml higher NT-proBNP level (p < 0.01), while, compared to the 1st quartile of adiponectin, the 2nd, 3rd and 4th quartiles had 28, 45 and 67% higher NT-proBNP levels (p < 0.01 for all). For changes in NT-proBNP over the follow-up period, and after multivariable adjustment including baseline NT-proBNP, a 1-SD increment in adiponectin was associated with a 25 pg/ml absolute increase in NT-proBNP (p < 0.01), while those in the 2nd, 3rd and 4th quartiles of adiponectin were associated with increases of 5, 28 and 65 pg/ml (p = 0.74, 0.09 and <0.01, respectively). There was a significant interaction between adiponectin and sex for visit 3 NT-proBNP (p-interaction < 0.01), with significantly stronger associations in men. Leptin was not associated with NT-proBNP. CONCLUSION: Higher adiponectin, but not leptin, is significantly associated with higher levels of NT-proBNP, as well as with greater longitudinal increases in NT-proBNP. The associations were stronger in men.
Authors: Clyde W Yancy; Mariell Jessup; Biykem Bozkurt; Javed Butler; Donald E Casey; Mark H Drazner; Gregg C Fonarow; Stephen A Geraci; Tamara Horwich; James L Januzzi; Maryl R Johnson; Edward K Kasper; Wayne C Levy; Frederick A Masoudi; Patrick E McBride; John J V McMurray; Judith E Mitchell; Pamela N Peterson; Barbara Riegel; Flora Sam; Lynne W Stevenson; W H Wilson Tang; Emily J Tsai; Bruce L Wilkoff Journal: J Am Coll Cardiol Date: 2013-06-05 Impact factor: 24.094
Authors: Michael H Criqui; Julie O Denenberg; Robyn L McClelland; Matthew A Allison; Joachim H Ix; Alan Guerci; Kevin P Cohoon; Preethi Srikanthan; Karol E Watson; Nathan D Wong Journal: Arterioscler Thromb Vasc Biol Date: 2014-05-08 Impact factor: 8.311
Authors: Matthew A Allison; David A Bluemke; Robyn McClelland; Mary Cushman; Michael H Criqui; Joseph F Polak; Joao A Lima Journal: Am J Cardiol Date: 2013-05-24 Impact factor: 2.778
Authors: Lori B Daniels; Matthew A Allison; Paul Clopton; Laura Redwine; Neil Siecke; Kenneth Taylor; Robert Fitzgerald; Mark Bracker; Alan S Maisel Journal: Int J Cardiol Date: 2007-03-28 Impact factor: 4.164
Authors: Eileen M Hsich; Maria V Grau-Sepulveda; Adrian F Hernandez; Zubin J Eapen; Ying Xian; Lee H Schwamm; Deepak L Bhatt; Gregg C Fonarow Journal: Am Heart J Date: 2013-10-22 Impact factor: 4.749
Authors: Diane E Bild; David A Bluemke; Gregory L Burke; Robert Detrano; Ana V Diez Roux; Aaron R Folsom; Philip Greenland; David R Jacob; Richard Kronmal; Kiang Liu; Jennifer Clark Nelson; Daniel O'Leary; Mohammed F Saad; Steven Shea; Moyses Szklo; Russell P Tracy Journal: Am J Epidemiol Date: 2002-11-01 Impact factor: 4.897
Authors: Steven R Horbal; Michael E Hall; Paul C Dinh; Abbas Smiley; Solomon K Musani; Jiankang Liu; Herman A Taylor; Ervin R Fox; Aurelian Bidulescu Journal: Cardiovasc Endocrinol Metab Date: 2020-05-15
Authors: Rosa M Agra; Ángel Fernández-Trasancos; Esther Díaz-Rodríguez; Alberto Cordero; Alfonso Varela-Román; Inés Gómez-Otero; J Nicolás López- Canoa; Ángel Luis Fernández; José Manuel Martínez-Cereijo; José Ramón González-Juanatey; Sonia Eiras Journal: Int J Med Sci Date: 2018-02-12 Impact factor: 3.738