Marcos Pérez-Carrasco1, Leonel Lagunes2, Andrés Antón3, Simone Gattarello2, César Laborda2, Tomás Pumarola3, Jordi Rello4. 1. Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Spain. Electronic address: marperez@vhebron.net. 2. Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Spain. 3. Department of Microbiology, Vall d'Hebron University Hospital, Barcelona, Spain. 4. Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Spain; Centro de Investigación Biomédica en Red: Enfermedades Respiratorias (CIBERes), Spain.
Abstract
UNLABELLED: The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE: To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of influenza-like illness (ILI), and to compare the features of pandemic vs. post-pandemic influenza A(H1N1) pdm09 infection. METHODS: A prospective observational study with SARI patients admitted to ICU during the first three post-pandemic seasons. Patient demographics, characteristics and outcomes were recorded. An influenza epidemic period (IEP) was defined as >100 cases/100,000 inhabitants per week. RESULTS: One hundred sixty-three patients were diagnosed with SARI. ILI was present in 65 (39.9%) patients. Influenza infection was documented in 41 patients, 27 (41.5%) ILI patients, and 14 (14.3%) non-ILI patients, 27 of them during an IEP. Influenza A viruses were mainly responsible. Only five patients had influenza B virus infection, which were non-ILI during an IEP. SARI overall mortality was 22.1%, and 15% in influenza infection patients. Pandemic and post-pandemic influenza infection patients shared similar clinical features. CONCLUSIONS: During influenza epidemic periods, influenza infection screening should be considered in all SARI patients. Influenza SARI was mainly caused by subtype A(H1N1)pdm09 and A(H3N2) in post-pandemic seasons, and no differences were observed in ILI and mortality rate compared with a pandemic season.
UNLABELLED: The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE: To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of influenza-like illness (ILI), and to compare the features of pandemic vs. post-pandemic influenza A(H1N1) pdm09 infection. METHODS: A prospective observational study with SARI patients admitted to ICU during the first three post-pandemic seasons. Patient demographics, characteristics and outcomes were recorded. An influenza epidemic period (IEP) was defined as >100 cases/100,000 inhabitants per week. RESULTS: One hundred sixty-three patients were diagnosed with SARI. ILI was present in 65 (39.9%) patients. Influenza infection was documented in 41 patients, 27 (41.5%) ILI patients, and 14 (14.3%) non-ILI patients, 27 of them during an IEP. Influenza A viruses were mainly responsible. Only five patients had influenza B virus infection, which were non-ILI during an IEP. SARI overall mortality was 22.1%, and 15% in influenza infectionpatients. Pandemic and post-pandemic influenza infectionpatients shared similar clinical features. CONCLUSIONS: During influenza epidemic periods, influenza infection screening should be considered in all SARI patients. Influenza SARI was mainly caused by subtype A(H1N1)pdm09 and A(H3N2) in post-pandemic seasons, and no differences were observed in ILI and mortality rate compared with a pandemic season.
Keywords:
A (H1N1) pdm09; A(H1N1)pdm09; Acute respiratory failure; Enfermedad tipo gripe; Infección respiratoria aguda grave; Influenza A virus; Influenza-like illness; Insuficiencia respiratoria aguda; Severe acute respiratory infection; Virus de la gripe A
Authors: Francisco Álvarez-Lerma; Judith Marín-Corral; Clara Vila; Joan Ramón Masclans; Francisco Javier González de Molina; Ignacio Martín Loeches; Sandra Barbadillo; Alejandro Rodríguez Journal: Crit Care Date: 2016-10-23 Impact factor: 9.097
Authors: Blanca Valenzuela-Méndez; Francisco Valenzuela-Sánchez; Juan Francisco Rodríguez-Gutiérrez; Rafael Bohollo-de-Austria; Ángel Estella; Pilar Martínez-García; María Ángela González-García; Jordi Rello Journal: J Pers Med Date: 2022-01-10