| Literature DB >> 26024438 |
Feng-Jiao Zhou1,2, Yin Nian3, Yongming Yan1,4, Ye Gong3, Qi Luo1,4, Yu Zhang1, Bo Hou1, Zhi-Li Zuo1, Shu-Mei Wang2, He-Hai Jiang3, Jian Yang3,5, Yong-Xian Cheng1.
Abstract
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (±)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.Entities:
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Year: 2015 PMID： 26024438 DOI： 10.1021/acs.orglett.5b01353
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005