| Literature DB >> 2602378 |
K W Plaxco1, A M Mathiowetz, W A Goddard.
Abstract
Molecular dynamics simulations were coupled with experimental data from biochemistry and genetics to generate a theoretical structure for the binding domain of Hin recombinase complexed with the hix site of DNA. The theoretical model explains the observed sequence specificity of Hin recombinase and leads to a number of testable predictions concerning altered sequence selectivity for various mutants of protein and DNA.Mesh：
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Year: 1989 PMID： 2602378 PMCID： PMC298598 DOI： 10.1073/pnas.86.24.9841
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205