Literature DB >> 2602359

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

D E Hallahan1, D R Spriggs, M A Beckett, D W Kufe, R R Weichselbaum.   

Abstract

We report that tumor necrosis factor alpha (TNF-alpha) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-alpha mRNA is accompanied by the increased production of TNF-alpha protein. TNF-alpha enhances radiation lethality in both TNF-alpha-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-alpha may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-alpha and therapeutic radiation may be useful in clinical cancer therapy.

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Year:  1989        PMID： 2602359      PMCID： PMC298653          DOI： 10.1073/pnas.86.24.10104

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Letter: The involvement of indirect effects in cell-killing and DNA double-strand breakage in gamma-irradiated Escherichia coli K-12.

Authors:  T Bonura; K C Smith
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1976-03

2.  Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.

Authors:  A J Fornace; B Zmudzka; M C Hollander; S H Wilson
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

3.  Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

Authors:  M P Bevilacqua; S Stengelin; M A Gimbrone; B Seed
Journal:  Science       Date:  1989-03-03       Impact factor: 47.728

4.  In vitro systems: standardization of endpoints.

Authors:  W C Dewey
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-08       Impact factor: 7.038

5.  DNA damage-inducible transcripts in mammalian cells.

Authors:  A J Fornace; I Alamo; M C Hollander
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

6.  Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts.

Authors:  R Miskin; R Ben-Ishai
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

7.  Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism.

Authors:  G H Wong; D V Goeddel
Journal:  Science       Date:  1988-11-11       Impact factor: 47.728

8.  X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders.

Authors:  R R Weichselbaum; J Nove; J B Little
Journal:  Cancer Res       Date:  1980-03       Impact factor: 12.701

9.  In vitro radiobiological parameters of human sarcoma cell lines.

Authors:  R R Weichselbaum; M A Beckett; M A Simon; C McCauley; D Haraf; A Awan; B Samuels; J Nachman; A Dritschilo
Journal:  Int J Radiat Oncol Biol Phys       Date:  1988-10       Impact factor: 7.038

10.  Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments.

Authors:  M Scanlon; S M Laster; J G Wood; L R Gooding
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205
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  107 in total

Review 1.  Early and late effects of radiation treatment for prevention of coronary restenosis: a critical appraisal.

Authors:  O F Bertrand; S Lehnert; R Mongrain; M G Bourassa
Journal:  Heart       Date:  1999-12       Impact factor: 5.994

2.  Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy.

Authors:  Lisa K Sprod; Oxana G Palesh; Michelle C Janelsins; Luke J Peppone; Charles E Heckler; M Jacob Adams; Gary R Morrow; Karen M Mustian
Journal:  Community Oncol       Date:  2010-10

3.  Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

Authors:  R Datta; E Rubin; V Sukhatme; S Qureshi; D Hallahan; R R Weichselbaum; D W Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

4.  Genistein can mitigate the effect of radiation on rat lung tissue.

Authors:  Victoria L Calveley; Salomeh Jelveh; Aimee Langan; Javed Mahmood; Ivan W T Yeung; Jake Van Dyk; Richard P Hill
Journal:  Radiat Res       Date:  2010-05       Impact factor: 2.841

5.  Ionizing radiation regulates expression of the c-jun protooncogene.

Authors:  M L Sherman; R Datta; D E Hallahan; R R Weichselbaum; D W Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

6.  Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.

Authors:  Roy Xiao; Clint T Allen; Linda Tran; Priya Patel; So-Jin Park; Zhong Chen; Carter Van Waes; Nicole C Schmitt
Journal:  Oncoimmunology       Date:  2018-08-01       Impact factor: 8.110

Review 7.  Exploiting sensitization windows of opportunity in hyper and hypo-fractionated radiation therapy.

Authors:  Anish Prasanna; Mansoor M Ahmed; Mohammed Mohiuddin; C Norman Coleman
Journal:  J Thorac Dis       Date:  2014-04       Impact factor: 2.895

Review 8.  DNA Damage and Repair Biomarkers of Immunotherapy Response.

Authors:  Kent W Mouw; Michael S Goldberg; Panagiotis A Konstantinopoulos; Alan D D'Andrea
Journal:  Cancer Discov       Date:  2017-06-19       Impact factor: 39.397

Review 9.  Linking the history of radiation biology to the hallmarks of cancer.

Authors:  Mary-Keara Boss; Robert Bristow; Mark W Dewhirst
Journal:  Radiat Res       Date:  2014-05-08       Impact factor: 2.841

Review 10.  Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.

Authors:  Carl N Sprung; Alesia Ivashkevich; Helen B Forrester; Christophe E Redon; Alexandros Georgakilas; Olga A Martin
Journal:  Cancer Lett       Date:  2013-09-14       Impact factor: 8.679
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