BACKGROUND: Diabetes Mellitus is a chronic metabolic disorder which may lead to various complications, the important being dyslipidemia leading to Coronary Heart Disorders (CHD), the major cause for morbidity and mortality in diabetic patients. Diabetes Mellitus could be treated by nutritional therapy/drug therapy and others. But the drug therapy would have its own limitations and side effects. To overcome from this an herbal extract is recommended, such as Diallyl Disulphide (DADS) a principle compound of Garlic oil. AIM: To assess the hypolipidemic effect of Diallyl Disulphide (DADS) in alloxan induced diabetic rats. MATERIALS AND METHODS: Healthy adult wistar strain male albino rats weighing around 100-150 grams were randomly selected from the animal house at BLDE University's Shri B.M.Patil Medical College, Hospital and Research Centre, Bijapur, India. Diabetes was induced using alloxan and was treated with DADS. After a stipulated time the rats were anesthetised and sacrificed to collect the blood and liver tissue. Various Lipid parameters, HMG CoA Reductase, Fecal bile acids were estimated in the blood, feces and homogenised liver tissue using standard procedures. STATISCAL ANALYSIS: One-way ANOVA followed by post-hoc t-test is done. RESULT: There was significant decrease in the blood and liver tissue lipid parameters of DADS treated alloxan induced diabetic rats when compared to the alloxan induced diabetic rats. CONCLUSION: From this study it can be concluded that the DADS a principle compound of garlic, definitely has the hypolipidemic effect in diabetic rats, which is reducing the morbidity in diabetic cases due to dyslipidemia without the adverse effects.
BACKGROUND:Diabetes Mellitus is a chronic metabolic disorder which may lead to various complications, the important being dyslipidemia leading to Coronary Heart Disorders (CHD), the major cause for morbidity and mortality in diabeticpatients. Diabetes Mellitus could be treated by nutritional therapy/drug therapy and others. But the drug therapy would have its own limitations and side effects. To overcome from this an herbal extract is recommended, such as Diallyl Disulphide (DADS) a principle compound of Garlic oil. AIM: To assess the hypolipidemic effect of Diallyl Disulphide (DADS) in alloxan induced diabeticrats. MATERIALS AND METHODS: Healthy adult wistar strain male albino rats weighing around 100-150 grams were randomly selected from the animal house at BLDE University's Shri B.M.Patil Medical College, Hospital and Research Centre, Bijapur, India. Diabetes was induced using alloxan and was treated with DADS. After a stipulated time the rats were anesthetised and sacrificed to collect the blood and liver tissue. Various Lipid parameters, HMG CoA Reductase, Fecal bile acids were estimated in the blood, feces and homogenised liver tissue using standard procedures. STATISCAL ANALYSIS: One-way ANOVA followed by post-hoc t-test is done. RESULT: There was significant decrease in the blood and liver tissue lipid parameters of DADS treated alloxan induced diabeticrats when compared to the alloxan induced diabeticrats. CONCLUSION: From this study it can be concluded that the DADS a principle compound of garlic, definitely has the hypolipidemic effect in diabeticrats, which is reducing the morbidity in diabetic cases due to dyslipidemia without the adverse effects.
Entities:
Keywords:
Diabetes mellitus; Dyslipidemia; HMG CoA Reductase
Authors: Yawen Zeng; Yuping Li; Jiazhen Yang; Xiaoying Pu; Juan Du; Xiaomeng Yang; Tao Yang; Shuming Yang Journal: Evid Based Complement Alternat Med Date: 2017-02-05 Impact factor: 2.629