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Literature DB >> 26022917

A niche role for cancer exosomes in metastasis.

Abstract

Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.

Entities: Disease

Mesh：

Substances：

Year: 2015 PMID： 26022917 DOI： 10.1038/ncb3181

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

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Authors: Christine L Chaffer; Robert A Weinberg
Journal: Science Date: 2011-03-25 Impact factor: 47.728

2. Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma.

Authors: Naotake Funamizu; Chaoxin Hu; Curtis Lacy; Aaron Schetter; Geng Zhang; Peijun He; Jochen Gaedcke; Michael B Ghadimi; Thomas Ried; Harris G Yfantis; Dong H Lee; Jeffrey Subleski; Tim Chan; Jonathan M Weiss; Timothy C Back; Katsuhiko Yanaga; Nader Hanna; H Richard Alexander; Anirban Maitra; S Perwez Hussain
Journal: Int J Cancer Date: 2013-02-15 Impact factor: 7.396

Review 3. Extracellular vesicles: biology and emerging therapeutic opportunities.

Authors: Samir EL Andaloussi; Imre Mäger; Xandra O Breakefield; Matthew J A Wood
Journal: Nat Rev Drug Discov Date: 2013-04-15 Impact factor: 84.694

Review 4. Tumor-cell-derived microvesicles as carriers of molecular information in cancer.

Authors: Vilma R Martins; Marcos S Dias; Pierre Hainaut
Journal: Curr Opin Oncol Date: 2013-01 Impact factor: 3.645

5. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.

Authors: Héctor Peinado; Maša Alečković; Simon Lavotshkin; Irina Matei; Bruno Costa-Silva; Gema Moreno-Bueno; Marta Hergueta-Redondo; Caitlin Williams; Guillermo García-Santos; Cyrus Ghajar; Ayuko Nitadori-Hoshino; Caitlin Hoffman; Karen Badal; Benjamin A Garcia; Margaret K Callahan; Jianda Yuan; Vilma R Martins; Johan Skog; Rosandra N Kaplan; Mary S Brady; Jedd D Wolchok; Paul B Chapman; Yibin Kang; Jacqueline Bromberg; David Lyden
Journal: Nat Med Date: 2012-06 Impact factor: 53.440

6. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Authors: Bruno Costa-Silva; Nicole M Aiello; Allyson J Ocean; Swarnima Singh; Haiying Zhang; Basant Kumar Thakur; Annette Becker; Ayuko Hoshino; Milica Tešić Mark; Henrik Molina; Jenny Xiang; Tuo Zhang; Till-Martin Theilen; Guillermo García-Santos; Caitlin Williams; Yonathan Ararso; Yujie Huang; Gonçalo Rodrigues; Tang-Long Shen; Knut Jørgen Labori; Inger Marie Bowitz Lothe; Elin H Kure; Jonathan Hernandez; Alexandre Doussot; Saya H Ebbesen; Paul M Grandgenett; Michael A Hollingsworth; Maneesh Jain; Kavita Mallya; Surinder K Batra; William R Jarnagin; Robert E Schwartz; Irina Matei; Héctor Peinado; Ben Z Stanger; Jacqueline Bromberg; David Lyden
Journal: Nat Cell Biol Date: 2015-05-18 Impact factor: 28.824

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Authors: Jaclyn Sceneay; Mark J Smyth; Andreas Möller
Journal: Cancer Metastasis Rev Date: 2013-12 Impact factor: 9.264

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Authors: Ann F Chambers; Alan C Groom; Ian C MacDonald
Journal: Nat Rev Cancer Date: 2002-08 Impact factor: 60.716

9. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.

Authors: Rosandra N Kaplan; Rebecca D Riba; Stergios Zacharoulis; Anna H Bramley; Loïc Vincent; Carla Costa; Daniel D MacDonald; David K Jin; Koji Shido; Scott A Kerns; Zhenping Zhu; Daniel Hicklin; Yan Wu; Jeffrey L Port; Nasser Altorki; Elisa R Port; Davide Ruggero; Sergey V Shmelkov; Kristian K Jensen; Shahin Rafii; David Lyden
Journal: Nature Date: 2005-12-08 Impact factor: 49.962

Review 10. Functions and therapeutic roles of exosomes in cancer.

Authors: Jacob A Tickner; Aaron J Urquhart; Sally-Anne Stephenson; Derek J Richard; Kenneth J O'Byrne
Journal: Front Oncol Date: 2014-05-27 Impact factor: 6.244

38 in total

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Journal: Proc Natl Acad Sci U S A Date: 2017-03-07 Impact factor: 11.205

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Journal: Am J Clin Exp Urol Date: 2021-02-15

4. Characterization of Protein Profiling and mRNA Expression of LLC Exosomes.

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Journal: Protein J Date: 2019-10 Impact factor: 2.371

5. Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities.

Authors: Luwen Zhang; Qiong Zhao; Hui Cang; Ziqiang Wang; Xiaojia Hu; Ruolang Pan; Yang Yang; Ye Chen
Journal: Adv Sci (Weinh) Date: 2022-03-20 Impact factor: 17.521