Anne Schwerk1, Jennifer Altschüler1, Manfred Roch2, Manfred Gossen2,3, Christine Winter4, Jürgen Berg1, Andreas Kurtz2,3, Levent Akyüz2,5, Barbara Steiner1. 1. 1Department of Neurology, Charité University Medicine, Berlin, Germany. 2. 2Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany. 3. 3Helmholtz-Zentrum Geesthacht (HZG), Institute of Biomaterial Science, Teltow, Germany. 4. 4Department of Psychiatry, Technical University Dresden, Germany. 5. 6Institute for Medical Immunology, Berlin, Germany.
Abstract
BACKGROUND: Mesenchymal stem cells (MSC) are easily harvested, and possess anti-inflammatory and trophic properties. Furthermore, MSC promote neuroprotection and neurogenesis, which could greatly benefit neurodegenerative disorders, such as Parkinson's disease. METHODS: MSC were transplanted one week after 6-hydroxydopamine lesioning and effects were evaluated after 6 months. RESULTS: MSC localized around the substantia nigra and the arachnoid mater, expressing pericyte and endothelial markers. MSC protected dopamine levels and upregulated peripheral anti-inflammatory cytokines. Furthermore, adipose-derived MSC increased neurogenesis in hippocampal and subventricular regions, and boosted memory functioning. CONCLUSION: Considering that hyposmia and loss of memory function are two major nonmotor symptoms in Parkinson's disease, transplants with modulatory effects on the hippocampus and subventricular zone could provide a disease-modifying therapy.
BACKGROUND: Mesenchymal stem cells (MSC) are easily harvested, and possess anti-inflammatory and trophic properties. Furthermore, MSC promote neuroprotection and neurogenesis, which could greatly benefit neurodegenerative disorders, such as Parkinson's disease. METHODS: MSC were transplanted one week after 6-hydroxydopamine lesioning and effects were evaluated after 6 months. RESULTS: MSC localized around the substantia nigra and the arachnoid mater, expressing pericyte and endothelial markers. MSC protected dopamine levels and upregulated peripheral anti-inflammatory cytokines. Furthermore, adipose-derived MSC increased neurogenesis in hippocampal and subventricular regions, and boosted memory functioning. CONCLUSION: Considering that hyposmia and loss of memory function are two major nonmotor symptoms in Parkinson's disease, transplants with modulatory effects on the hippocampus and subventricular zone could provide a disease-modifying therapy.
Authors: C Marin-Bañasco; K Benabdellah; C Melero-Jerez; B Oliver; M J Pinto-Medel; I Hurtado-Guerrero; F de Castro; D Clemente; O Fernández; F Martin; L Leyva; M Suardíaz Journal: Br J Pharmacol Date: 2017-01-12 Impact factor: 8.739