Michiro Takahashi1, Kiyoshi Hasegawa1, Masaru Oba1, Taku Aoki1, Yoshihiro Sakamoto1, Yasuhiko Sugawara1, Norihiro Kokudo2. 1. Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. 2. Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: KOKUDO-2SU@h.u-tokyo.ac.jp.
Abstract
BACKGROUND: Some reports have shown that a significant number of patients experience recurrence, even after 5 or more years after surgery for colorectal liver metastases (CLMs). This study aimed to determine the actual cure rate and identify clinical characteristics among long-term survivors. METHODS: A prospectively maintained database was used to retrospectively review patients who underwent liver resection for CLM between 1994 and 2001. RESULTS: A total of 130 patients underwent liver resection for CLM with a complete 10-year follow-up. The 10-year disease-specific survival rate was 31.1%, and the survival curve reached a plateau after 10 years from the time of hepatic resection. There were 35 actual 10-year survivors. Multivariate analysis revealed that female patients and those with negative surgical margins were independent prognostic factors for disease-specific survival. CONCLUSION: A 10-year survival following initial hepatectomy should be defined as cure.
BACKGROUND: Some reports have shown that a significant number of patients experience recurrence, even after 5 or more years after surgery for colorectal liver metastases (CLMs). This study aimed to determine the actual cure rate and identify clinical characteristics among long-term survivors. METHODS: A prospectively maintained database was used to retrospectively review patients who underwent liver resection for CLM between 1994 and 2001. RESULTS: A total of 130 patients underwent liver resection for CLM with a complete 10-year follow-up. The 10-year disease-specific survival rate was 31.1%, and the survival curve reached a plateau after 10 years from the time of hepatic resection. There were 35 actual 10-year survivors. Multivariate analysis revealed that female patients and those with negative surgical margins were independent prognostic factors for disease-specific survival. CONCLUSION: A 10-year survival following initial hepatectomy should be defined as cure.
Authors: Wong Hoi She; Tan To Cheung; Simon H Y Tsang; Wing Chiu Dai; Ka On Lam; Albert C Y Chan; Chung Mau Lo Journal: Langenbecks Arch Surg Date: 2022-08-26 Impact factor: 2.895