Thomas Braschler1, Cora Alexandra Vökt2, Hein Hustinx3, Thierry Peyrard4, Laura Infanti1, Andreas Buser1, Andreas Holbro1. 1. Division of Hematology, University Hospital, Basel, Switzerland ; Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland. 2. Department of Obstetrics and Gynecology, University Hospital, Basel, Switzerland. 3. Blood Transfusion Service, Swiss Red Cross, Berne, Switzerland. 4. Institut National de la Transfusion Sanguine (INTS), Département Centre National de Référence pour les Groupes Sanguins, Paris, France.
Abstract
BACKGROUND: Holley (Hy) is a high-incidence antigen of the Dombrock blood group system (ISBT 014), present in almost 100% of most populations and more than 99% of Blacks. Since anti-Hy is an extremely rare antibody, data on its clinical relevance and in particular on a possible hemolytic disease of the fetus and newborn (HDFN) are scarce. CASE REPORT: The pregnant patient underwent two autologous whole blood collections at weeks 17 and 19 of gestation with cryopreservation. In our case autologous whole blood collection was well tolerated. There were no signs of HDFN in the healthy newborn. CONCLUSION: Our case improves our understanding of anti-Hy alloantibodies during pregnancy. Additionally, autologous whole blood collection of RBC units with cryopreservation is a safe and feasible way to manage pregnancies in women with rare alloantibodies, when no compatible donor can be found.
BACKGROUND: Holley (Hy) is a high-incidence antigen of the Dombrock blood group system (ISBT 014), present in almost 100% of most populations and more than 99% of Blacks. Since anti-Hy is an extremely rare antibody, data on its clinical relevance and in particular on a possible hemolytic disease of the fetus and newborn (HDFN) are scarce. CASE REPORT: The pregnant patient underwent two autologous whole blood collections at weeks 17 and 19 of gestation with cryopreservation. In our case autologous whole blood collection was well tolerated. There were no signs of HDFN in the healthy newborn. CONCLUSION: Our case improves our understanding of anti-Hy alloantibodies during pregnancy. Additionally, autologous whole blood collection of RBC units with cryopreservation is a safe and feasible way to manage pregnancies in women with rare alloantibodies, when no compatible donor can be found.
Entities:
Keywords:
Anti-Holley alloantibody; HDFN; Hemolytic disease of the fetus and newborn; Pregnancy