Literature DB >> 26018892

Hypertension linked to PDE3A activation.

Miles Houslay1.   

Abstract

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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Year:  2015        PMID： 26018892     DOI： 10.1038/ng.3316

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  3 in total

1.  Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States.

Authors:  Hege E Larsen; Emma N Bardsley; Konstantinos Lefkimmiatis; David J Paterson
Journal:  J Neurosci       Date:  2016-08-17       Impact factor: 6.167

2.  Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:  Ayush Giri; Jacklyn N Hellwege; Jacob M Keaton; Jihwan Park; Chengxiang Qiu; Helen R Warren; Eric S Torstenson; Csaba P Kovesdy; Yan V Sun; Otis D Wilson; Cassianne Robinson-Cohen; Christianne L Roumie; Cecilia P Chung; Kelly A Birdwell; Scott M Damrauer; Scott L DuVall; Derek Klarin; Kelly Cho; Yu Wang; Evangelos Evangelou; Claudia P Cabrera; Louise V Wain; Rojesh Shrestha; Brian S Mautz; Elvis A Akwo; Muralidharan Sargurupremraj; Stéphanie Debette; Michael Boehnke; Laura J Scott; Jian'an Luan; Jing-Hua Zhao; Sara M Willems; Sébastien Thériault; Nabi Shah; Christopher Oldmeadow; Peter Almgren; Ruifang Li-Gao; Niek Verweij; Thibaud S Boutin; Massimo Mangino; Ioanna Ntalla; Elena Feofanova; Praveen Surendran; James P Cook; Savita Karthikeyan; Najim Lahrouchi; Chunyu Liu; Nuno Sepúlveda; Tom G Richardson; Aldi Kraja; Philippe Amouyel; Martin Farrall; Neil R Poulter; Markku Laakso; Eleftheria Zeggini; Peter Sever; Robert A Scott; Claudia Langenberg; Nicholas J Wareham; David Conen; Colin Neil Alexander Palmer; John Attia; Daniel I Chasman; Paul M Ridker; Olle Melander; Dennis Owen Mook-Kanamori; Pim van der Harst; Francesco Cucca; David Schlessinger; Caroline Hayward; Tim D Spector; Marjo-Riitta Jarvelin; Branwen J Hennig; Nicholas J Timpson; Wei-Qi Wei; Joshua C Smith; Yaomin Xu; Michael E Matheny; Edward E Siew; Cecilia Lindgren; Karl-Heinz Herzig; George Dedoussis; Joshua C Denny; Bruce M Psaty; Joanna M M Howson; Patricia B Munroe; Christopher Newton-Cheh; Mark J Caulfield; Paul Elliott; J Michael Gaziano; John Concato; Peter W F Wilson; Philip S Tsao; Digna R Velez Edwards; Katalin Susztak; Christopher J O'Donnell; Adriana M Hung; Todd L Edwards
Journal:  Nat Genet       Date:  2018-12-21       Impact factor: 38.330

3.  Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation.

Authors:  Julia Hoppmann; Julia Gesing; Caroline Silve; Chrystel Leroy; Astrid Bertsche; Franz Wolfgang Hirsch; Wieland Kiess; Roland Pfäffle; Volker Schuster
Journal:  J Clin Res Pediatr Endocrinol       Date:  2017-05-17
  3 in total

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