Gabriel Victor Guimarães Rapello1, Andréia Antoniolli2, Daniel Martins Pereira1, Gilberto Facco3, Paulo Manuel Pêgo-Fernandes4, Rogério Pazetti5. 1. Hospital Regional de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brasil. 2. Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brasil. 3. Universidade Anhanguera-Uniderp, Campo Grande, Mato Grosso do Sul, Brasil. 4. Instituto do Coração (InCor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil. 5. Laboratory of Thoracic Surgery Research, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, Brasil.
Abstract
CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university. METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm). RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48). CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.
CONTEXT AND OBJECTIVE:Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university. METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm). RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48). CONCLUSION:Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with humanpulmonary emphysema.
Authors: Giuseppe Gava; Simon B Eickhoff; Timm J Filler; Felix Mayer; Nina S Mahlke; Stefanie Ritz-Timme Journal: Int J Legal Med Date: 2021-06-28 Impact factor: 2.686