Literature DB >> 2601885

Chloride and magnesium dependence of vasopressin release from rat permeabilized neurohypophysial nerve endings.

G Dayanithi1, J J Nordmann.   

Abstract

The role of Cl- and Mg+ ions has been studied on the secretory mechanism leading to the release of vasopressin from digitonin permeabilized nerve endings isolated from the rat neurohypophysis. Secretion was triggered by challenging the permeabilized nerve endings with 1.1 microM free Ca2+. Magnesium enhances secretion and its maximal effect occurred at a concentration of about 2 mM. Further increase of this divalent cation concentration however led to an inhibition of secretion. Chloride ions are necessary for the final steps in exocytosis and this effect of Cl- was inhibited by the chloride channel antagonist N144. It is concluded that in neurosecretory nerve endings magnesium and chloride ions are crucial components for exocytosis to occur.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2601885     DOI： 10.1016/0304-3940(89)90181-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.

Authors:  J Z Chuang; T A Milner; M Zhu; C H Sung
Journal:  J Neurosci       Date:  1999-04-15       Impact factor: 6.167

2.  Subcellular distribution and targeting of the intracellular chloride channel p64.

Authors:  C Redhead; S K Sullivan; C Koseki; K Fujiwara; J C Edwards
Journal:  Mol Biol Cell       Date:  1997-04       Impact factor: 4.138

Review 3.  The signaling role for chloride in the bidirectional communication between neurons and astrocytes.

Authors:  Corinne S Wilson; Alexander A Mongin
Journal:  Neurosci Lett       Date:  2018-01-09       Impact factor: 3.046

4.  Transport of gamma-aminobutyrate and L-glutamate into synaptic vesicles. Effect of different inhibitors on the vesicular uptake of neurotransmitters and on the Mg2(+)-ATPase.

Authors:  E M Fykse; F Fonnum
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

5.  Intracellular Cl- modulates Ca2+-induced exocytosis from rat melanotrophs through GTP-binding proteins.

Authors:  M Rupnik; R Zorec
Journal:  Pflugers Arch       Date:  1995-11       Impact factor: 3.657

6.  Sodium-evoked, calcium-independent vasopressin release from rat isolated neurohypophysial nerve endings.

Authors:  E L Stuenkel; J J Nordmann
Journal:  J Physiol       Date:  1993-08       Impact factor: 5.182

7.  Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway.

Authors:  Barbara Ulmasov; Jonathan Bruno; Nicarter Gordon; M Elizabeth Hartnett; John C Edwards
Journal:  Am J Pathol       Date:  2009-02-05       Impact factor: 4.307
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.