Literature DB >> 26018709

Ectopic ACTH and CRH Co-secreting Tumor Localized by 68Ga-DOTA-TATE PET/CT.

Georgios Z Papadakis1, Ulas Bagci, Samira M Sadowski, Nicholas J Patronas, Constantine A Stratakis.   

Abstract

Diagnosis of ectopic adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) co-secreting tumors causing Cushing syndrome (CS) is challenging because these tumors are rare and their diagnosis is frequently confused with Cushing disease (CD), caused by the effect of CRH on the pituitary. We report a case of a 21-year-old male patient who was referred to our institution with persistent hypercortisolemia and CS after undergoing unnecessary transsphenoidal surgery (TSS). ⁶⁸Ga-DOTA-TATE PET/CT revealed increased tracer uptake in the thymus, which was histologically proven to be a neuroendocrine tumor (NET) that stained positive for ACTH and CRH. Imaging with ¹⁸F-FDG PET/CT was not diagnostic.

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Year:  2015        PMID： 26018709      PMCID： PMC4459884          DOI： 10.1097/RLU.0000000000000806

Source DB:  PubMed          Journal:  Clin Nucl Med        ISSN： 0363-9762            Impact factor:   7.794


  15 in total

1.  Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE.

Authors:  Irene Virgolini; Valentina Ambrosini; Jamshed B Bomanji; Richard P Baum; Stefano Fanti; Michael Gabriel; Nikolaos D Papathanasiou; Giovanna Pepe; Wim Oyen; Clemens De Cristoforo; Arturo Chiti
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-10       Impact factor: 9.236

2.  ⁶⁸Ga-DOTATOC PET-CT in the localization of source of ectopic ACTH in patients with ectopic ACTH-dependent Cushing's syndrome.

Authors:  Balasubramanian Venkitaraman; Sellam Karunanithi; Arvind Kumar; Chandrasekhar Bal; Ariachery C Ammini; Rakesh Kumar
Journal:  Clin Imaging       Date:  2013-11-07       Impact factor: 1.605

3.  Cushing's syndrome due to a corticotropin-releasing hormone- and adrenocorticotrophic hormone-producing neuroendocrine pancreatic tumor.

Authors:  Nina Sauer; Clarissa Schulze zur Wiesch; Jörg Flitsch; Wolfgang Saeger; Susanne Klutmann; Jozef Zustin; Andreas Luebke; Jens Aberle
Journal:  Endocr Pract       Date:  2014-04       Impact factor: 3.443

4.  Functional imaging of neuroendocrine tumors with combined PET/CT using 68Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) and 18F-FDG.

Authors:  Irfan Kayani; Jamshed B Bomanji; Ashley Groves; Gerard Conway; Sveto Gacinovic; Thida Win; John Dickson; Martyn Caplin; Peter Joseph Ell
Journal:  Cancer       Date:  2008-06       Impact factor: 6.860

5.  Ectopic Cushing's syndrome due to concurrent corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) secreted by malignant gastrinoma.

Authors:  S Y Park; Y Rhee; J C Youn; Y N Park; S Lee; D M Kim; S Y Song; S-K Lim
Journal:  Exp Clin Endocrinol Diabetes       Date:  2007-01       Impact factor: 2.949

6.  The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors.

Authors:  Alexander R Haug; Ramona Cindea-Drimus; Christoph J Auernhammer; Martin Reincke; Björn Wängler; Christopher Uebleis; Gerwin P Schmidt; Burkhard Göke; Peter Bartenstein; Marcus Hacker
Journal:  J Nucl Med       Date:  2012-09-14       Impact factor: 10.057

7.  The role of [(18)F]fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome.

Authors:  Karel Pacak; Ioannis Ilias; Clara C Chen; Jorge A Carrasquillo; Millie Whatley; Lynnette K Nieman
Journal:  J Clin Endocrinol Metab       Date:  2004-05       Impact factor: 5.958

8.  A comparison of 68Ga-DOTATATE and 18F-FDG PET/CT in pulmonary neuroendocrine tumors.

Authors:  Irfan Kayani; Brendon G Conry; Ashley M Groves; Thida Win; John Dickson; Martyn Caplin; Jamshed B Bomanji
Journal:  J Nucl Med       Date:  2009-11-12       Impact factor: 10.057

9.  Cushing's syndrome due to ectopic production of corticotropin-releasing hormone in an infant with ganglioneuroblastoma.

Authors:  Farhad Zangeneh; William F Young; Ricardo V Lloyd; Myra Chiang; Elizabeth Kurczynski; Fereydoun Zangeneh
Journal:  Endocr Pract       Date:  2003 Sep-Oct       Impact factor: 3.443

Review 10.  Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature.

Authors:  Sadeka Shahani; Rodolfo J Nudelman; Ramaswami Nalini; Han-Seob Kim; Susan L Samson
Journal:  Diagn Pathol       Date:  2010-08-31       Impact factor: 2.644
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  13 in total

Review 1.  Diagnostic utility of Gallium-68-somatostatin receptor PET/CT in ectopic ACTH-secreting tumors: a systematic literature review and single-center clinical experience.

Authors:  Elena Varlamov; José Miguel Hinojosa-Amaya; Madeleine Stack; Maria Fleseriu
Journal:  Pituitary       Date:  2019-10       Impact factor: 4.107

Review 2.  Ectopic cushing's syndrome due to corticotropin releasing hormone.

Authors:  Manouchehr Nakhjavani; Alireza Amirbaigloo; Soghra Rabizadeh; Fabio Rotondo; Kalman Kovacs; Ali A Ghazi
Journal:  Pituitary       Date:  2019-10       Impact factor: 4.107

3.  Ectopic corticotropin-releasing hormone syndrome caused by pancreatic neuroendocrine tumor localized by 68Ga-DOTATATE PET/CT.

Authors:  Guozhu Hou; Yuanyuan Jiang; Wuying Cheng
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-12-05       Impact factor: 9.236

4.  Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Samira M Sadowski; Apostolos H Karantanas; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2017-03       Impact factor: 7.794

5.  Kidney Tumor in a von Hippel-Lindau (VHL) Patient With Intensely Increased Activity on 68Ga-DOTA-TATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Samira M Sadowski; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2016-12       Impact factor: 7.794

6.  Breast Fibroadenoma With Increased Activity on 68Ga DOTATATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Samira M Sadowski; Apostolos H Karantanas; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2017-02       Impact factor: 7.794

7.  Avascular Necrosis of the Hips With Increased Activity on 68Ga-DOTATATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Apostolos H Karantanas; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2017-03       Impact factor: 7.794

8.  Cushing's Syndrome Due to CRH and ACTH Co-secreting Pancreatic Tumor--Presentation of a New Case Focusing on Diagnostic Pitfalls.

Authors:  Athanasios Fountas; Zoe Giotaki; Nikos Ligkros; Efthymia D Tsakiridou; Stelios Tigas; Wolfgang Saeger; Agathocles Tsatsoulis
Journal:  Endocr Pathol       Date:  2015-09       Impact factor: 3.943

9.  Epididymal Cystadenomas in von Hippel-Lindau Disease Showing Increased Activity on 68Ga DOTATATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Samira M Sadowski; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2016-10       Impact factor: 7.794

10.  Endolymphatic Sac Tumor Showing Increased Activity on 68Ga DOTATATE PET/CT.

Authors:  Georgios Z Papadakis; Corina Millo; Samira M Sadowski; Ulas Bagci; Nicholas J Patronas
Journal:  Clin Nucl Med       Date:  2016-10       Impact factor: 7.794
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