Literature DB >> 26018232

Morin: A Promising Natural Drug.

Anna Caselli, Paolo Cirri, Alice Santi, Paolo Paoli1.   

Abstract

Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial effect on several human diseases. In fact, Morin exerts antioxidant, antidiabetic, anti-inflammatory, antitumoral, antihypertensive, antibacterial, hypouricemic, and neuroprotective effects, by modulating the activity of many enzymes. In some cases, Morin shows a systemic protective action, reducing negative side effects of several drugs, without interfering with their functions. In addition, in vitro and in vivo studies demonstrated that Morin exhibits very low toxicity levels and its chronic administration is well tolerated. All these findings suggest that Morin could be used, either alone or in combination with other drugs, to prevent many human pathologies.

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Year:  2016        PMID: 26018232     DOI: 10.2174/0929867323666160106150821

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN: 0929-8673            Impact factor:   4.530


  41 in total

1.  Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-Like Symptoms.

Authors:  Benneth Ben-Azu; Adegbuyi Oladele Aderibigbe; Aya-Ebi Okubo Eneni; Abayomi Mayowa Ajayi; Solomon Umukoro; Ezekiel O Iwalewa
Journal:  Neurochem Res       Date:  2018-06-28       Impact factor: 3.996

2.  Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase.

Authors:  Amon Amini; Mason Liu; Zulfiqar Ahmad
Journal:  Int J Biol Macromol       Date:  2017-03-18       Impact factor: 6.953

3.  Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth.

Authors:  Mason Liu; Amon Amini; Zulfiqar Ahmad
Journal:  Int J Biol Macromol       Date:  2016-11-16       Impact factor: 6.953

4.  Identification of morin as an agonist of imidazoline I-3 receptor for insulin secretion in diabetic rats.

Authors:  Mang Hung Lin; Chia-Chen Hsu; Jenshinn Lin; Juei-Tang Cheng; Ming Chang Wu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-07-08       Impact factor: 3.000

5.  Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases.

Authors:  Ming Gu; Yu Zhang; Chuhe Liu; Dongshan Wang; Li Feng; Shengjie Fan; Baican Yang; Qingchun Tong; Guang Ji; Cheng Huang
Journal:  Br J Pharmacol       Date:  2017-08-11       Impact factor: 8.739

6.  Morin Inhibits Dox-Induced Vascular Inflammation By Regulating PTEN/AKT/NF-κB Pathway.

Authors:  Jing Yu; Hai-Liang Qi; Hong Zhang; Zi-Yu Zhao; Zi-Yuan Nie
Journal:  Inflammation       Date:  2022-06-15       Impact factor: 4.092

7.  Morin Augmented Myocardial eNOS/cGMP/PKG Signaling Pathway and Abated Oxidative and Inflammo-apoptotic Responses in Diethyl Phthalate and Bisphenol-S Co-Exposed Male Albino Rats.

Authors:  Adewale Segun James; Ofem Effiom Eteng; Oluwatosin Adebisi Dosumu; Ceasar Antiya Moses; Chukwuka Uzoamaka Ogbonna; Oladokun Abdulwasiu Adeleye; Emmanuel Ifeanyichukwu Ugwor; Blessing Chukwueku Omilo; Risikat Funmilayo Fabunmi; Aduragbemi Moses Olakitan; Regina Ngozi Ugbaja
Journal:  Inflammation       Date:  2022-07-28       Impact factor: 4.657

8.  ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth.

Authors:  Mohammed Tarique; Manish Chauhan; Renu Tuteja
Journal:  Protoplasma       Date:  2016-09-14       Impact factor: 3.356

Review 9.  Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks.

Authors:  Alessandra V S Faria; Emanuella Maria Barreto Fonseca; Helon Guimarães Cordeiro; Stefano Piatto Clerici; Carmen Veríssima Ferreira-Halder
Journal:  Cell Mol Life Sci       Date:  2020-10-14       Impact factor: 9.261

Review 10.  Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases.

Authors:  Peng Zhou; Fang Hua; Xiang Wang; Jin-Ling Huang
Journal:  Inflammopharmacology       Date:  2020-01-01       Impact factor: 4.473

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