[The metabolic pathways of concanavalin A action on the chemosensitivity of the neuronal membrane].

It has been shown that concanavaline A (Co A) inhibited those acetylcholine (ACh) and gamma-aminobutyric acid (GABA) responses of the membrane of dialyzed snail neurons which were blocked by ouabain. The inhibitory effect of Co A on these responses was removed at 5 degrees C. Co A had no significant influence on ACh responses which were insensitive to ouabain. Co A inhibited ACh-induced 86Rb+ ions efflux from the neurons preliminarily enriched by these ions. Co A has exerted a stimulating effect on the phosphorylation of neuronal membrane fractions. In this case Co A decreased the intracellular cyclic adenozine monophosphate (cAMP) content and increased the intracellular content of cyclic guanozine monophosphate. It is supposed that cAMP-independent membrane phosphorylation underlies the Co A inhibiting effect on the neuronal membrane sensitivity to ACh and GABA.