Kalinca da Silva Oliveira1, Caroline Buss2, Cristiane Valle Tovo1. 1. Programa de Pós-Graduação em Medicina - Departamento de Hepatologia, UFCSPA, Porto Alegre, RS, Brasil. 2. Departamento de Nutrição, UFCSPA, Porto Alegre, RS, Brasil.
Abstract
BACKGROUND: Caffeine consumption has been associated to decreased levels of liver enzymes and lower risk of fibrosis in patients with hepatitis C virus. Objectives This study aimed to evaluate the association between caffeine consumption and inflammatory activity or degree of liver fibrosis in patients with hepatitis C virus infection. METHODS: A cross-sectional study of patients with chronic hepatitis C virus infection treated in an outpatient Gastroenterology Unit of Santa Casa Hospital (Porto Alegre - Brasil). Patients were interviewed regarding the consumption of caffeine and anthropometric assessment was performed. Liver biopsy was performed in a maximum period of 36 months before inclusion in the study. RESULTS: There were 113 patients, 67 (59.3%) females, 48 (42.5%) were aged between 52 and 62 years, and 101 (89.4%) were white. The average caffeine consumption was 251.41 ± 232.32 mg/day, and 70 (62%) patients consumed up to 250 mg/day of caffeine. There was no association between caffeine consumption and inflammatory activity on liver biopsy. On the other hand, when evaluating the caffeine consumption liver fibrosis an inverse association was observed. CONCLUSIONS: The greater consumption of caffeine was associated with lower liver fibrosis. There was no association between caffeine consumption and inflammatory activity.
BACKGROUND: Caffeine consumption has been associated to decreased levels of liver enzymes and lower risk of fibrosis in patients with hepatitis C virus. Objectives This study aimed to evaluate the association between caffeine consumption and inflammatory activity or degree of liver fibrosis in patients with hepatitis C virus infection. METHODS: A cross-sectional study of patients with chronic hepatitis C virus infection treated in an outpatient Gastroenterology Unit of Santa Casa Hospital (Porto Alegre - Brasil). Patients were interviewed regarding the consumption of caffeine and anthropometric assessment was performed. Liver biopsy was performed in a maximum period of 36 months before inclusion in the study. RESULTS: There were 113 patients, 67 (59.3%) females, 48 (42.5%) were aged between 52 and 62 years, and 101 (89.4%) were white. The average caffeine consumption was 251.41 ± 232.32 mg/day, and 70 (62%) patients consumed up to 250 mg/day of caffeine. There was no association between caffeine consumption and inflammatory activity on liver biopsy. On the other hand, when evaluating the caffeine consumption liver fibrosis an inverse association was observed. CONCLUSIONS: The greater consumption of caffeine was associated with lower liver fibrosis. There was no association between caffeine consumption and inflammatory activity.
Authors: Nicola Veronese; Maria Notarnicola; Anna Maria Cisternino; Rosa Reddavide; Rosa Inguaggiato; Vito Guerra; Ornella Rotolo; Iris Zinzi; Gioacchino Leandro; Mario Correale; Valeria Tutino; Giovanni Misciagna; Alberto Ruben Osella; Caterina Bonfiglio; Gianluigi Giannelli; Maria Gabriella Caruso Journal: Nutrients Date: 2018-01-15 Impact factor: 5.717