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Literature DB >> 26016722

One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines.

Ahmad Shaabani¹, Mozhdeh Seyyedhamzeh², Nasim Ganji², Mona Hamidzad Sangachin², Mahsa Armaghan³.

Abstract

A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of p-toluenesulfonic acid in water within 4-6 h.

Entities: Chemical

Keywords: Green chemistry; MCRs; Multicomponent reaction; Triazolopyrimidine; Water

Mesh：

Substances：

Year: 2015 PMID： 26016722 DOI： 10.1007/s11030-015-9604-4

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

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3. Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.

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4. New one-pot four-component synthesis of disubstituted pyrido[2,3-d]pyrimidine-6-carboxamide derivatives.

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5. Studies on cardiovascular agents. 6. Synthesis and coronary vasodilating and antihypertensive activities of 1,2,4-triazolo[1,5-a]pyrimidines fused to heterocyclic systems.

Authors: Y Sato; Y Shimoji; H Fujita; H Nishino; H Mizuno; S Kobayashi; S Kumakura
Journal: J Med Chem Date: 1980-08 Impact factor: 7.446

6. Fluorinated 1,2,4-Triazolo[1,5-a]pyrimidine-6-carboxylic acid derivatives as antimycobacterial agents.

Authors: Hamdy M Abdel-Rahman; Nawal A El-Koussi; Hoda Y Hassan
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7. One-pot synthesis of coumarin-3-carboxamides containing a triazole ring via an isocyanide-based six-component reaction.

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Journal: ACS Comb Sci Date: 2014-02-24 Impact factor: 3.784

8. A novel one-pot three-(in situ five-)component condensation reaction: an unexpected approach for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5]diazepine-3-yl-2-methylpropanamide derivatives.

Authors: Ahmad Shaabani; Ali Hossein Rezayan; Sajjad Keshipour; Afshin Sarvary; Seik Weng Ng
Journal: Org Lett Date: 2009-08-06 Impact factor: 6.005

9. Synthesis, antifungal activity and CoMFA analysis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives.

Authors: Qiong Chen; Xiao-Lei Zhu; Li-Li Jiang; Zu-Ming Liu; Guang-Fu Yang
Journal: Eur J Med Chem Date: 2007-05-27 Impact factor: 6.514

10. 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents.

Authors: T Novinson; R H Springer; D E O'Brien; M B Scholten; J P Miller; R K Robins
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