INTRODUCTION: Seborrhoeic dermatitis affects a variable proportion of the general population, ranging from 3% to 10%. Malassezia yeast species (previously referred to as Pityrosporum) are thought to be the responsible organisms, and cause inflammation by still poorly defined mechanisms. Seborrhoeic dermatitis tends to relapse after treatment. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of topical treatments for seborrhoeic dermatitis of the scalp in adults? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 14 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: bifonazole, ciclopirox, ketoconazole, pyrithione zinc, selenium sulfide, tar shampoo, terbinafine, and topical corticosteroids (betamethasone valerate, clobetasol propionate, clobetasone butyrate, hydrocortisone, mometasone furoate).
INTRODUCTION:Seborrhoeic dermatitis affects a variable proportion of the general population, ranging from 3% to 10%. Malassezia yeast species (previously referred to as Pityrosporum) are thought to be the responsible organisms, and cause inflammation by still poorly defined mechanisms. Seborrhoeic dermatitis tends to relapse after treatment. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of topical treatments for seborrhoeic dermatitis of the scalp in adults? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 14 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: bifonazole, ciclopirox, ketoconazole, pyrithione zinc, selenium sulfide, tar shampoo, terbinafine, and topical corticosteroids (betamethasone valerate, clobetasol propionate, clobetasone butyrate, hydrocortisone, mometasone furoate).
Authors: Raza Aly; H Irving Katz; Steven E Kempers; Donald P Lookingbill; Nicholas Lowe; Alan Menter; Manuel Morman; Ronald C Savin; Mitchell Wortzman Journal: Int J Dermatol Date: 2003-09 Impact factor: 2.736
Authors: P Bailey; C Arrowsmith; K Darling; J Dexter; J Eklund; A Lane; C Little; B Murray; A Scott; A Williams; D Wilson Journal: Int J Cosmet Sci Date: 2003-08 Impact factor: 2.970
Authors: Kaat De Cremer; Katrijn De Brucker; Ines Staes; Annelies Peeters; Freija Van den Driessche; Tom Coenye; Bruno P A Cammue; Karin Thevissen Journal: Sci Rep Date: 2016-06-07 Impact factor: 4.379
Authors: Natalie G Robinett; Edward M Culbertson; Ryan L Peterson; Hiram Sanchez; David R Andes; Jeniel E Nett; Valeria C Culotta Journal: J Biol Chem Date: 2018-12-28 Impact factor: 5.157