Chenjiao Zhang1, Jianrong Du2, Zhixiang Peng3. 1. Department of Operative Dentistry and Endodontics, Guanghua School and Hospital of Stomatology, Institute of Stomatological Research, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. 2. Department of Stomatology, Guangdong No. 2 Provincial People's Hospital, Guangdong, China. 3. Department of Operative Dentistry and Endodontics, Guanghua School and Hospital of Stomatology, Institute of Stomatological Research, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: 13430371987@163.com.
Abstract
INTRODUCTION: The relationship between Enterococcus faecalis and pulpal or periradicular diseases has been studied for many years; however, whether E. faecalis is correlated with persistent intraradicular infections (teeth after failed endodontic treatments) compared with primary intraradicular infections remains controversial. The objective of this systematic review was to compare the prevalence of E. faecalis in primary and persistent intraradicular infections. METHODS: An exhaustive literature search combined with specified inclusion criteria was performed to collect all studies comparing the prevalence of E. faecalis in root canals with primary and persistent intraradicular infections. Descriptive statistics were applied first because of the high heterogeneity among studies. Subgroup analysis according to different detecting methods (culture and polymerase chain reaction) and sensitivity analysis was then applied. Meta-analysis was conducted with the help of Stata/SE 12.0 (StataCorp, College Station, TX) after excluding studies with uncertain forms of pulpal and periradicular lesions in their primary infection groups. RESULTS: The systematic review included 10 studies covering 972 teeth. Among them, 2 studies used the culture technique, 6 studies used polymerase chain reaction, and the other 2 used both techniques. The detection rate of E. faecalis by both methods was higher in persistent infections compared with untreated chronic periapical periodontitis as primary infections. The difference was statistically significant (odds ratio = 7.247; 95% confidence interval, 4.039-13.002). CONCLUSIONS: E. faecalis is more highly correlated with persistent intraradicular infections compared with untreated chronic periapical periodontitis.
INTRODUCTION: The relationship between Enterococcus faecalis and pulpal or periradicular diseases has been studied for many years; however, whether E. faecalis is correlated with persistent intraradicular infections (teeth after failed endodontic treatments) compared with primary intraradicular infections remains controversial. The objective of this systematic review was to compare the prevalence of E. faecalis in primary and persistent intraradicular infections. METHODS: An exhaustive literature search combined with specified inclusion criteria was performed to collect all studies comparing the prevalence of E. faecalis in root canals with primary and persistent intraradicular infections. Descriptive statistics were applied first because of the high heterogeneity among studies. Subgroup analysis according to different detecting methods (culture and polymerase chain reaction) and sensitivity analysis was then applied. Meta-analysis was conducted with the help of Stata/SE 12.0 (StataCorp, College Station, TX) after excluding studies with uncertain forms of pulpal and periradicular lesions in their primary infection groups. RESULTS: The systematic review included 10 studies covering 972 teeth. Among them, 2 studies used the culture technique, 6 studies used polymerase chain reaction, and the other 2 used both techniques. The detection rate of E. faecalis by both methods was higher in persistent infections compared with untreated chronic periapical periodontitis as primary infections. The difference was statistically significant (odds ratio = 7.247; 95% confidence interval, 4.039-13.002). CONCLUSIONS:E. faecalis is more highly correlated with persistent intraradicular infections compared with untreated chronic periapical periodontitis.
Authors: Alfonso López-Marrufo-Medina; Laura Domínguez-Domínguez; Daniel Cabanillas-Balsera; Victoria Areal-Quecuty; Isabel Crespo-Gallardo; Mª Carmen Jiménez-Sánchez; José López-López; Juan J Segura-Egea; Jenifer Martin-Gonzalez Journal: J Clin Exp Dent Date: 2022-01-01
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Authors: Islam Ali Abdel Raheem; Amro Abdul Razek; Abeer Abdelaziz Elgendy; Noha Mohamed Saleh; Mona Ibrahem Shaaban; Faten K Abd El-Hady Journal: Int J Nanomedicine Date: 2019-10-21