Ruben Crespo-Diaz1, Satsuki Yamada1, Jozef Bartunek2, Carmen Perez-Terzic1,3, Peter de Waele4, Sébastien Mauën4, Andre Terzic1, Atta Behfar1. 1. Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA. 2. Cardiovascular Center, OLV Hospital, Aalst, Belgium. 3. Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA. 4. Celyad BioSciences, Mont-Saint-Guibert, Belgium.
Abstract
BACKGROUND: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. AIM: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. MATERIALS & METHODS: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. RESULTS: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. CONCLUSION: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.
BACKGROUND: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. AIM: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. MATERIALS & METHODS: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. RESULTS: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. CONCLUSION: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.
Authors: Rosalinda Madonna; Linda W Van Laake; Hans Erik Botker; Sean M Davidson; Raffaele De Caterina; Felix B Engel; Thomas Eschenhagen; Francesco Fernandez-Aviles; Derek J Hausenloy; Jean-Sebastien Hulot; Sandrine Lecour; Jonathan Leor; Philippe Menasché; Maurizio Pesce; Cinzia Perrino; Fabrice Prunier; Sophie Van Linthout; Kirsti Ytrehus; Wolfram-Hubertus Zimmermann; Peter Ferdinandy; Joost P G Sluijter Journal: Cardiovasc Res Date: 2019-03-01 Impact factor: 10.787
Authors: Jozef Bartunek; Andre Terzic; Beth A Davison; Atta Behfar; Ricardo Sanz-Ruiz; Wojciech Wojakowski; Warren Sherman; Guy R Heyndrickx; Marco Metra; Gerasimos S Filippatos; Scott A Waldman; John R Teerlink; Timothy D Henry; Bernard J Gersh; Roger Hajjar; Michal Tendera; Stefanie Senger; Gad Cotter; Thomas J Povsic; William Wijns Journal: ESC Heart Fail Date: 2020-10-23
Authors: D Kent Arrell; Ruben J Crespo-Diaz; Satsuki Yamada; Ryounghoon Jeon; Armin Garmany; Sungjo Park; Jeffrey P Adolf; Christopher Livia; Matthew L Hillestad; Jozef Bartunek; Atta Behfar; Andre Terzic Journal: Stem Cells Transl Med Date: 2021-05-28 Impact factor: 6.940