Literature DB >> 26014720

First total synthesis of (+)-epogymnolactam, a novel autophagy inducer.

Yuji Okado1, Kengo Shigetomi1, Shinya Mitsuhashi1, Makoto Ubukata1.   

Abstract

A novel autophagy inducer, (+)-epogymnolactam (1), was first synthesized from cis-4-benzyloxy-2-butene-1-ol (2) in eight steps. A reliable preparation of optically pure epoxy alcohol (+)-3 from monobenzyl derivative (2) was established by a tandem strategy, Sharpless epoxidation/lipase kinetic resolution.

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Year:  2015        PMID： 26014720     DOI： 10.1038/ja.2015.63

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  19 in total

1.  A new versatile synthesis of cerulenin.

Authors:  J Furukawa; H Funabashi; N Morisaki; S Iwasaki; S Okuda
Journal:  Chem Pharm Bull (Tokyo)       Date:  1988-03       Impact factor: 1.645

2.  Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin.

Authors:  Y Sato; S Nomura; Y Kamio; S Omura; T Hata
Journal:  J Antibiot (Tokyo)       Date:  1967-11       Impact factor: 2.649

3.  Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity.

Authors:  Jae-Kyo Jeong; Myung-Hee Moon; Bum-Chul Bae; You-Jin Lee; Jae-Won Seol; Hyung-Sub Kang; Jin-Shang Kim; Seog-Jin Kang; Sang-Youel Park
Journal:  Neurosci Res       Date:  2012-03-23       Impact factor: 3.304

4.  Binding site of cerulenin in fatty acid synthetase.

Authors:  H Funabashi; A Kawaguchi; H Tomoda; S Omura; S Okuda; S Iwasaki
Journal:  J Biochem       Date:  1989-05       Impact factor: 3.387

5.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Authors:  Brinda Ravikumar; Coralie Vacher; Zdenek Berger; Janet E Davies; Shouqing Luo; Lourdes G Oroz; Francesco Scaravilli; Douglas F Easton; Rainer Duden; Cahir J O'Kane; David C Rubinsztein
Journal:  Nat Genet       Date:  2004-05-16       Impact factor: 38.330

6.  (+)-Epogymnolactam, a novel autophagy inducer from mycelial culture of Gymnopus sp.

Authors:  Shinya Mitsuhashi; Chihaya Shindo; Kengo Shigetomi; Toshizumi Miyamoto; Makoto Ubukata
Journal:  Phytochemistry       Date:  2014-09-18       Impact factor: 4.072

7.  Identification of a candidate therapeutic autophagy-inducing peptide.

Authors:  Sanae Shoji-Kawata; Rhea Sumpter; Matthew Leveno; Grant R Campbell; Zhongju Zou; Lisa Kinch; Angela D Wilkins; Qihua Sun; Kathrin Pallauf; Donna MacDuff; Carlos Huerta; Herbert W Virgin; J Bernd Helms; Ruud Eerland; Sharon A Tooze; Ramnik Xavier; Deborah J Lenschow; Ai Yamamoto; David King; Olivier Lichtarge; Nick V Grishin; Stephen A Spector; Dora V Kaloyanova; Beth Levine
Journal:  Nature       Date:  2013-01-30       Impact factor: 49.962

8.  The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

Authors:  Randall M Chin; Xudong Fu; Melody Y Pai; Laurent Vergnes; Heejun Hwang; Gang Deng; Simon Diep; Brett Lomenick; Vijaykumar S Meli; Gabriela C Monsalve; Eileen Hu; Stephen A Whelan; Jennifer X Wang; Gwanghyun Jung; Gregory M Solis; Farbod Fazlollahi; Chitrada Kaweeteerawat; Austin Quach; Mahta Nili; Abby S Krall; Hilary A Godwin; Helena R Chang; Kym F Faull; Feng Guo; Meisheng Jiang; Sunia A Trauger; Alan Saghatelian; Daniel Braas; Heather R Christofk; Catherine F Clarke; Michael A Teitell; Michael Petrascheck; Karen Reue; Michael E Jung; Alison R Frand; Jing Huang
Journal:  Nature       Date:  2014-05-14       Impact factor: 49.962

Review 9.  Autophagy modulation as a potential therapeutic target for diverse diseases.

Authors:  David C Rubinsztein; Patrice Codogno; Beth Levine
Journal:  Nat Rev Drug Discov       Date:  2012-09       Impact factor: 84.694

10.  Lithium induces autophagy by inhibiting inositol monophosphatase.

Authors:  Sovan Sarkar; R Andres Floto; Zdenek Berger; Sara Imarisio; Axelle Cordenier; Matthieu Pasco; Lynnette J Cook; David C Rubinsztein
Journal:  J Cell Biol       Date:  2005-09-26       Impact factor: 10.539
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