Özgür Yaldizli1, Matteo Pardini2, Varun Sethi3, Nils Muhlert4, Zheng Liu5, Daniel J Tozer3, Rebecca S Samson3, Claudia Am Wheeler-Kingshott3, Tarek A Yousry6, David H Miller7, Declan T Chard7. 1. Queen Square MS Centre, UCL Institute of Neurology, UK/MS Center, University Hospital Basel, Switzerland o.yaldizli@ucl.ac.uk. 2. Queen Square MS Centre, UCL Institute of Neurology, UK/Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy. 3. Queen Square MS Centre, UCL Institute of Neurology, UK. 4. Queen Square MS Centre, UCL Institute of Neurology, UK/School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff University, UK. 5. Queen Square MS Centre, UCL Institute of Neurology, UK/Department of Neurology, Xuanwu Hospital of Capital Medical University, China. 6. Queen Square MS Centre, UCL Institute of Neurology, UK/National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre, UK/Brain Repair and Rehabilitation, UCL Institute of Neurology, UK/Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UK. 7. Queen Square MS Centre, UCL Institute of Neurology, UK/National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre, UK.
Abstract
BACKGROUND: In multiple sclerosis (MS), diffusion tensor and magnetisation transfer imaging are both abnormal in lesional and extra-lesional cortical grey matter, but differences between clinical subtypes and associations with clinical outcomes have only been partly assessed. OBJECTIVE: To compare mean diffusivity, fractional anisotropy and magnetisation transfer ratio (MTR) in cortical grey matter lesions (detected using phase-sensitive inversion recovery (PSIR) imaging) and extra-lesional cortical grey matter, and assess associations with disability in relapse-onset MS. METHODS: Seventy-two people with MS (46 relapsing-remitting (RR), 26 secondary progressive (SP)) and 36 healthy controls were included in this study. MTR, mean diffusivity and fractional anisotropy were measured in lesional and extra-lesional cortical grey matter. RESULTS: Mean fractional anisotropy was higher and MTR lower in lesional compared with extra-lesional cortical grey matter. In extra-lesional cortical grey matter mean fractional anisotropy and MTR were lower, and mean diffusivity was higher in the MS group compared with controls. Mean MTR was lower and mean diffusivity was higher in lesional and extra-lesional cortical grey matter in SPMS when compared with RRMS. These differences were independent of disease duration. In multivariate analyses, MTR in extra-lesional more so than lesional cortical grey matter was associated with disability. CONCLUSION: Magnetic resonance abnormalities in lesional and extra-lesional cortical grey matter are greater in SPMS than RRMS. Changes in extra-lesional compared with lesional cortical grey matter are more consistently associated with disability.
BACKGROUND: In multiple sclerosis (MS), diffusion tensor and magnetisation transfer imaging are both abnormal in lesional and extra-lesional cortical grey matter, but differences between clinical subtypes and associations with clinical outcomes have only been partly assessed. OBJECTIVE: To compare mean diffusivity, fractional anisotropy and magnetisation transfer ratio (MTR) in cortical grey matter lesions (detected using phase-sensitive inversion recovery (PSIR) imaging) and extra-lesional cortical grey matter, and assess associations with disability in relapse-onset MS. METHODS: Seventy-two people with MS (46 relapsing-remitting (RR), 26 secondary progressive (SP)) and 36 healthy controls were included in this study. MTR, mean diffusivity and fractional anisotropy were measured in lesional and extra-lesional cortical grey matter. RESULTS: Mean fractional anisotropy was higher and MTR lower in lesional compared with extra-lesional cortical grey matter. In extra-lesional cortical grey matter mean fractional anisotropy and MTR were lower, and mean diffusivity was higher in the MS group compared with controls. Mean MTR was lower and mean diffusivity was higher in lesional and extra-lesional cortical grey matter in SPMS when compared with RRMS. These differences were independent of disease duration. In multivariate analyses, MTR in extra-lesional more so than lesional cortical grey matter was associated with disability. CONCLUSION: Magnetic resonance abnormalities in lesional and extra-lesional cortical grey matter are greater in SPMS than RRMS. Changes in extra-lesional compared with lesional cortical grey matter are more consistently associated with disability.
Authors: Tobias Granberg; Qiuyun Fan; Constantina Andrada Treaba; Russell Ouellette; Elena Herranz; Gabriel Mangeat; Céline Louapre; Julien Cohen-Adad; Eric C Klawiter; Jacob A Sloane; Caterina Mainero Journal: Brain Date: 2017-11-01 Impact factor: 13.501
Authors: Torben Schneider; W Brownlee; H Zhang; Olga Ciccarelli; David H Miller; Claudia Gandini Wheeler-Kingshott Journal: Funct Neurol Date: 2017 Apr/Jun