| Literature DB >> 26014367 |
Roman Neufeld1, Michael John1, Dietmar Stalke2.
Abstract
Lithium diisopropyl amide (LDA) is a very prominent reagent that plays a key role in organic synthesis, serving as a base par excellence for a broad range of deprotonation reactions. However, the state of aggregation in solution in the absence of donor bases was unclear. In this paper we solved this problem by employing DOSY NMR experiments based on a newly elaborated external calibration curve (ECC) approach with normalized diffusion coefficients.Entities:
Keywords: NMR spectroscopy; aggregation; lithium amides; reactive intermediates
Year: 2015 PMID： 26014367 DOI： 10.1002/anie.201502576
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336