Yuichi Nodake1, Saki Matsumoto2, Ryoko Miura2, Hidetoshi Honda3, Genji Ishibashi4, Shuzo Matsumoto5, Itaru Dekio6, Ryuzo Sakakibara7. 1. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan. Electronic address: nodake@niu.ac.jp. 2. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan; Research and Development Department, BIOGENOMICS Co., Ltd., 147-40 Masuragahara, Omura, Nagasaki 856-0022, Japan. 3. Research and Development Department, BIOGENOMICS Co., Ltd., 147-40 Masuragahara, Omura, Nagasaki 856-0022, Japan. 4. Department of Nutrition, Kyushu Women's University, 1-1 Jiyugaoka, Yahatanishi-ku, Kitakyushu 807-8586, Japan. 5. Applied Technology Division, Industrial Technology Center of Nagasaki, 2-1303-8 Ikeda, Omura, Nagasaki 856-0026, Japan. 6. Department of Dermatology, Medical Centre East, Tokyo Women's Medical University, 2-1-10 Nishi-Ogu, Arakawa, Tokyo 116-8567, Japan. 7. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan.
Abstract
BACKGROUND AND OBJECTIVE: Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS: We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pilot study, in which S. epidermidis was collected from the subject, cultured for proliferation, and then continuously applied to the subject's own face before sleep twice per week for four weeks in order to increase colonization levels. RESULTS: The results showed that this treatment increased the lipid content of the skin and suppressed water evaporation, thereby markedly improving skin moisture retention. Moreover, augmentation with S. epidermidis maintained a low acidic condition on the skin surface. The low risk of undesirable effects induced by augmentation with S. epidermidis was also confirmed by measuring erythema and melanin levels. CONCLUSIONS: These results may serve as a driving force to accelerate the development of novel, personalized basic cosmetics.
RCT Entities:
BACKGROUND AND OBJECTIVE:Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS: We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pilot study, in which S. epidermidis was collected from the subject, cultured for proliferation, and then continuously applied to the subject's own face before sleep twice per week for four weeks in order to increase colonization levels. RESULTS: The results showed that this treatment increased the lipid content of the skin and suppressed water evaporation, thereby markedly improving skin moisture retention. Moreover, augmentation with S. epidermidis maintained a low acidic condition on the skin surface. The low risk of undesirable effects induced by augmentation with S. epidermidis was also confirmed by measuring erythema and melanin levels. CONCLUSIONS: These results may serve as a driving force to accelerate the development of novel, personalized basic cosmetics.
Authors: Bernhard Paetzold; Jesse R Willis; João Pereira de Lima; Nastassia Knödlseder; Holger Brüggemann; Sven R Quist; Toni Gabaldón; Marc Güell Journal: Microbiome Date: 2019-06-24 Impact factor: 14.650
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Authors: David Dodds; Jeffrey L Bose; Ming-De Deng; Gilles R Dubé; Trudy H Grossman; Alaina Kaiser; Kashmira Kulkarni; Roger Leger; Sara Mootien-Boyd; Azim Munivar; Julia Oh; Matthew Pestrak; Komal Rajpura; Alexander P Tikhonov; Traci Turecek; Travis Whitfill Journal: mSphere Date: 2020-06-10 Impact factor: 4.389