| Literature DB >> 26012550 |
Antonella Sassano1, Evangelos Mavrommatis2, Ahmet Dirim Arslan2, Barbara Kroczynska3, Elspeth M Beauchamp1, Satya Khuon2, Ten-Leong Chew2, Kathleen J Green4, Hidayatullah G Munshi1, Amit K Verma5, Leonidas C Platanias6.
Abstract
We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26012550 PMCID： PMC4524119 DOI： 10.1128/MCB.00019-15
Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272