Literature DB >> 26012476

Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil.

H Balasubramanian1, T Strunk2, R Kohan2.   

Abstract

We report significant hypotension and prerenal failure in an extremely preterm infant following two doses of oral sildenafil that warranted discontinuation of the drug and treatment with inotropes. Blood pressure and urine output normalized after 24 h of withdrawal of the oral drug. Sildenafil should be used cautiously in extremely preterm infants early in the neonatal course, where there is limited data on its efficacy and safety.

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Year:  2015        PMID： 26012476     DOI： 10.1038/jp.2015.31

Source DB:  PubMed          Journal:  J Perinatol        ISSN： 0743-8346            Impact factor:   2.521


  8 in total

Review 1.  Sildenafil for pulmonary hypertension in neonates.

Authors:  Prakeshkumar S Shah; Arne Ohlsson
Journal:  Cochrane Database Syst Rev       Date:  2011-08-10

2.  Population pharmacokinetics of sildenafil in term neonates: evidence of rapid maturation of metabolic clearance in the early postnatal period.

Authors:  A Mukherjee; T Dombi; B Wittke; R Lalonde
Journal:  Clin Pharmacol Ther       Date:  2008-09-17       Impact factor: 6.875

3.  STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension.

Authors:  Robyn J Barst; Maurice Beghetti; Tomas Pulido; Gary Layton; Irina Konourina; Min Zhang; D Dunbar Ivy
Journal:  Circulation       Date:  2014-03-17       Impact factor: 29.690

4.  Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children.

Authors:  Poongundran Namachivayam; Ulf Theilen; Warwick W Butt; Sian M Cooper; Daniel J Penny; Lara S Shekerdemian
Journal:  Am J Respir Crit Care Med       Date:  2006-08-17       Impact factor: 21.405

Review 5.  The utility of sildenafil in pulmonary hypertension: a focus on bronchopulmonary dysplasia.

Authors:  Andrew James Wardle; Richard Wardle; Karen Luyt; Robert Tulloh
Journal:  Arch Dis Child       Date:  2013-04-26       Impact factor: 3.791

6.  The effect of sildenafil on evolving bronchopulmonary dysplasia in extremely preterm infants: a randomised controlled pilot study.

Authors:  Kai König; Charles P Barfield; Katelyn J Guy; Sandra M Drew; Chad C Andersen
Journal:  J Matern Fetal Neonatal Med       Date:  2013-08-08

7.  Sildenafil exposure in neonates with pulmonary hypertension after administration via a nasogastric tube.

Authors:  Maurice J Ahsman; Bregje C Witjes; Enno D Wildschut; Ilona Sluiter; Arnold G Vulto; Dick Tibboel; Ron A Mathot
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2009-11-30       Impact factor: 5.747

8.  [Sildenafil and nitric oxide inhalation in neonatal pulmonary hypertension. Three case reports].

Authors:  G Cavallaro; E Agazzani; L Andaloro; C Bottura; G Cristofori; P Mussini; F Sacco; G Compagnoni
Journal:  Pediatr Med Chir       Date:  2008 May-Jun
  8 in total
  2 in total

Review 1.  Controversies in the identification and management of acute pulmonary hypertension in preterm neonates.

Authors:  Regan E Giesinger; Kiran More; Jodie Odame; Amish Jain; Robert P Jankov; Patrick J McNamara
Journal:  Pediatr Res       Date:  2017-10-04       Impact factor: 3.756

2.  Sildenafil Exposure in the Neonatal Intensive Care Unit.

Authors:  Elizabeth J Thompson; Krystle Perez; Christoph P Hornik; P Brian Smith; Reese H Clark; Matthew Laughon
Journal:  Am J Perinatol       Date:  2018-08-06       Impact factor: 3.079
  2 in total

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