Literature DB >> 26011650

Serotonin: A New Hope in Alzheimer's Disease?

Sylvie Claeysen1,2,3, Joël Bockaert1,2,3, Patrizia Giannoni1,2,3.   

Abstract

Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.

Entities:  

Keywords:  5-HT4 receptors; 5-HT6 receptors; Serotonin; neuroprotection

Mesh：

Substances：

Year:  2015        PMID： 26011650     DOI： 10.1021/acschemneuro.5b00135

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


  25 in total

Review 1.  Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.

Authors:  Vincent C Lombardi; Kenny L De Meirleir; Krishnamurthy Subramanian; Sam M Nourani; Ruben K Dagda; Shannon L Delaney; András Palotás
Journal:  J Nutr Biochem       Date:  2018-04-19       Impact factor: 6.048

2.  N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties.

Authors:  Paweł Zajdel; Krzysztof Marciniec; Grzegorz Satała; Vittorio Canale; Tomasz Kos; Anna Partyka; Magdalena Jastrzębska-Więsek; Anna Wesołowska; Agnieszka Basińska-Ziobroń; Jacek Wójcikowski; Władysława A Daniel; Andrzej J Bojarski; Piotr Popik
Journal:  ACS Med Chem Lett       Date:  2016-04-07       Impact factor: 4.345

Review 3.  Nano-biosensors to detect beta-amyloid for Alzheimer's disease management.

Authors:  Ajeet Kaushik; Rahul Dev Jayant; Sneham Tiwari; Arti Vashist; Madhavan Nair
Journal:  Biosens Bioelectron       Date:  2016-01-28       Impact factor: 10.618

4.  5-Hydroxytryptamine receptor 6 antagonist, SB258585 exerts neuroprotection in a rat model of Streptozotocin-induced Alzheimer's disease.

Authors:  Nasrin Hashemi-Firouzi; Siamak Shahidi; Sara Soleimani-Asl; Alireza Komaki
Journal:  Metab Brain Dis       Date:  2018-04-17       Impact factor: 3.584

5.  Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation.

Authors:  Anas Shamsi; Debarati DasGupta; Fahad A Alhumaydhi; Mohd Shahnawaz Khan; Suliman A Alsagaby; Waleed Al Abdulmonem; Md Imtaiyaz Hassan; Dharmendra Kumar Yadav
Journal:  RSC Med Chem       Date:  2022-04-20

Review 6.  Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.

Authors:  Giuseppe Di Giovanni; Dubravka Svob Strac; Montse Sole; Mercedes Unzeta; Keith F Tipton; Dorotea Mück-Šeler; Irene Bolea; Laura Della Corte; Matea Nikolac Perkovic; Nela Pivac; Ilse J Smolders; Anna Stasiak; Wieslawa A Fogel; Philippe De Deurwaerdère
Journal:  Front Neurosci       Date:  2016-11-24       Impact factor: 4.677

7.  Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.

Authors:  Arubala P Reddy; Xiangling Yin; Neha Sawant; P Hemachandra Reddy
Journal:  Hum Mol Genet       Date:  2021-05-29       Impact factor: 6.150

Review 8.  Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection.

Authors:  Xiaolei Wang; Smriti Mehra; Deepak Kaushal; Ronald S Veazey; Huanbin Xu
Journal:  Front Microbiol       Date:  2021-06-28       Impact factor: 5.640

Review 9.  Serotonin, neural markers, and memory.

Authors:  Alfredo Meneses
Journal:  Front Pharmacol       Date:  2015-07-21       Impact factor: 5.810

Review 10.  The neurogenic niche in Alzheimer's disease.

Authors:  Connor M Wander; Juan Song
Journal:  Neurosci Lett       Date:  2021-07-13       Impact factor: 3.197
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