P Brandon Bookstaver1, Jenna L Foster2, Z Kevin Lu1, Joshua R Mann3, Chelsea Ambrose4, Amy Grant5, Stephanie Burgess6. 1. a Department of Clinical Pharmacy & Outcomes Sciences , SC College of Pharmacy, University of South Carolina , Columbia , South Carolina , USA. 2. b Department of Pharmacy , Palmetto Health Richland , Columbia , South Carolina , USA. 3. c Department of Preventive Medicine , University of Mississippi , Jackson , Mississippi , USA. 4. d Triad Isotopes, Richmond , Virginia , USA. 5. e SC College of Pharmacy, University of South Carolina , Columbia , South Carolina , USA. 6. f College of Nursing, University of South Carolina , Columbia , South Carolina , USA.
Abstract
OBJECTIVE: To investigate the hepatitis B virus (HBV) seroconversion rate among health sciences students. PARTICIPANTS: The study included pharmacy, doctor of nursing, and medical students over 18 years of age enrolled at the University of South Carolina between 2007 and 2011. METHODS: The primary end point was HBV seroconversion rates among students at the initial reporting period. Seroconversion was defined as hepatitis B surface antibody (anti-HBs) level greater than or equal to 10 mIU/mL. Multivariate regression analysis was used to determine predictive factors of seroconversion. RESULTS: Of 777 records, data were available for 709 students. An 83.9% seroconversion rate was observed after a mean of 10 years between vaccine receipt and anti-HBs evaluation. Students with incomplete HBV vaccine series and longer time between initial series and evaluation were less likely to exhibit antibody response. CONCLUSIONS: These data highlight the importance of assessment and documentation of HBV vaccination series among health sciences students prior to direct patient care activities.
OBJECTIVE: To investigate the hepatitis B virus (HBV) seroconversion rate among health sciences students. PARTICIPANTS: The study included pharmacy, doctor of nursing, and medical students over 18 years of age enrolled at the University of South Carolina between 2007 and 2011. METHODS: The primary end point was HBV seroconversion rates among students at the initial reporting period. Seroconversion was defined as hepatitis B surface antibody (anti-HBs) level greater than or equal to 10 mIU/mL. Multivariate regression analysis was used to determine predictive factors of seroconversion. RESULTS: Of 777 records, data were available for 709 students. An 83.9% seroconversion rate was observed after a mean of 10 years between vaccine receipt and anti-HBs evaluation. Students with incomplete HBV vaccine series and longer time between initial series and evaluation were less likely to exhibit antibody response. CONCLUSIONS: These data highlight the importance of assessment and documentation of HBV vaccination series among health sciences students prior to direct patient care activities.
Entities:
Keywords:
Health education; health sciences; hepatitis B virus; immunization; seroconversion; students, titer