Yongsheng Yuan1, Qing Tong1, Li Zhang1, Siming Jiang1, Hong Zhou2, Rui Zhang3, Shu Zhang4, Qinrong Xu1, Daqian Li5, Xiaobin Zhou6, Jian Ding1, Kezhong Zhang1. 1. a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China. 2. b Department of Neurology , Jiangsu Shengze Hospital , Wujiang , China. 3. c Department of Neurosurgery , Nanjing Children's Hospital of Nanjing Medical University , Nanjing , China. 4. d Clinical Research Center , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China. 5. e Department of Laboratory Medicine , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China. 6. f Department of Microbiology and Immunology , Nanjing Medical University , Nanjing , China.
Abstract
PURPOSE: This study aimed to explore plasma antioxidant status in de novo Chinese Parkinson's disease (PD) patients and investigate its relationship with specific motor features of PD. PATIENTS AND METHODS: Sixty-four de novo Chinese PD patients and 40 age- and sex-matched healthy controls were recruited. Each motor feature of PD patients was assessed by unified Parkinson's disease rating scale. Plasma antioxidant status, including plasma level of glutathione (GSH) and plasma activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), was detected using enzyme-linked immunosorbent assay. The relationship between the plasma antioxidant status and motor features of PD was evaluated by Spearman's coefficient. RESULTS: Plasma GSH level and plasma activities of GSH-Px, CAT and SOD of PD patients were lower than those of healthy controls. Moreover, the declining activity of plasma CAT was related with the increasing mean postural instability and gait disorder (PIGD) score and growing age. In contrast, the severity of tremor was positively correlated with plasma SOD activity. CONCLUSION: Our study demonstrates that the plasma antioxidant status is impaired in de novo Chinese PD patients. The complex relationship between the plasma antioxidant status and different motor features indicates that the antioxidant mechanisms underlying tremor and PIGD of PD may be different.
PURPOSE: This study aimed to explore plasma antioxidant status in de novo Chinese Parkinson's disease (PD) patients and investigate its relationship with specific motor features of PD. PATIENTS AND METHODS: Sixty-four de novo Chinese PDpatients and 40 age- and sex-matched healthy controls were recruited. Each motor feature of PDpatients was assessed by unified Parkinson's disease rating scale. Plasma antioxidant status, including plasma level of glutathione (GSH) and plasma activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), was detected using enzyme-linked immunosorbent assay. The relationship between the plasma antioxidant status and motor features of PD was evaluated by Spearman's coefficient. RESULTS: Plasma GSH level and plasma activities of GSH-Px, CAT and SOD of PDpatients were lower than those of healthy controls. Moreover, the declining activity of plasma CAT was related with the increasing mean postural instability and gait disorder (PIGD) score and growing age. In contrast, the severity of tremor was positively correlated with plasma SOD activity. CONCLUSION: Our study demonstrates that the plasma antioxidant status is impaired in de novo Chinese PDpatients. The complex relationship between the plasma antioxidant status and different motor features indicates that the antioxidant mechanisms underlying tremor and PIGD of PD may be different.
Authors: G L Delogu; F Pintus; L Mayán; M J Matos; S Vilar; J Munín; J A Fontenla; G Hripcsak; F Borges; D Viña Journal: Medchemcomm Date: 2017-07-07 Impact factor: 3.597
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