| Literature DB >> 26009179 |
Monika Seidel1, F Anthony Lai1, Spyros Zissimopoulos1.
Abstract
The ryanodine receptor/Ca2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation-contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses on channel regulation through structural intra- and inter-subunit interactions and their implications in ryanodine receptor pathophysiology.Entities:
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Year: 2015 PMID: 26009179 DOI: 10.1042/BST20140292
Source DB: PubMed Journal: Biochem Soc Trans ISSN: 0300-5127 Impact factor: 5.407