Jesse W Lloyd1, Kristin A Evans2, Kristy M Zerfass3, Michael E Holmstrup4, Jill A Kanaley5, Stefan Keslacy6. 1. Department of Exercise Science, Syracuse University, Syracuse, NY 13244, United States. Electronic address: jwlloyd@syr.edu. 2. Department of Public Health Sciences, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642, United States. Electronic address: kristin_evans@urmc.rochester.edu. 3. Department of Exercise Science, Syracuse University, Syracuse, NY 13244, United States. Electronic address: kmzerfas@syr.edu. 4. Department of Exercise and Rehabilitative Sciences, Slippery Rock University, Slippery Rock, PA 16057, United States. Electronic address: michael.holmstrup@sru.edu. 5. Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, MO 65211, United States. Electronic address: kanaleyj@missouri.edu. 6. School of Kinesiology and Nutritional Science, California State University, Los Angeles, CA 90032, United States. Electronic address: skeslac@calstatela.edu.
Abstract
AIMS: Serum chemerin concentrations are elevated in obese individuals and may play a role in type 2 diabetes. Exercise improves insulin sensitivity, which may be related to changes in chemerin. This study explored how an acute bout of aerobic exercise affected chemerin levels in non-diabetic obese adults. METHODS: Blood samples from 11 obese adults were obtained during two separate conditions: sedentary (SED) and exercise (EX; 60-65% VO2peak). Samples were drawn at baseline, immediately following exercise and hourly for an additional 2h. ANOVA was used to test for differences in chemerin between conditions. RESULTS: Unadjusted analysis showed no difference in overall change (baseline to 2h post) in chemerin between conditions. During the 2-h post-exercise period, chemerin decreased to 12% below baseline, compared to a 2.5% increase above baseline during that time period on the sedentary day (p=0.06, difference in post-to-2h change between conditions). Controlling for homeostatic model assessment of insulin resistance (HOMA-IR), a significant difference existed between EX and SED in the change in chemerin from baseline to 2-h post (p=0.02). Stratified analyses showed a consistent exercise-induced decrease in chemerin among non-insulin resistant subjects, while chemerin increased during exercise among insulin resistant subjects, and then decreased post-exercise. CONCLUSION: An acute bout of exercise in obese individuals may elicit a drop in chemerin levels during the post-exercise period, and this response may vary based on insulin resistance.
AIMS: Serum chemerin concentrations are elevated in obese individuals and may play a role in type 2 diabetes. Exercise improves insulin sensitivity, which may be related to changes in chemerin. This study explored how an acute bout of aerobic exercise affected chemerin levels in non-diabetic obese adults. METHODS: Blood samples from 11 obese adults were obtained during two separate conditions: sedentary (SED) and exercise (EX; 60-65% VO2peak). Samples were drawn at baseline, immediately following exercise and hourly for an additional 2h. ANOVA was used to test for differences in chemerin between conditions. RESULTS: Unadjusted analysis showed no difference in overall change (baseline to 2h post) in chemerin between conditions. During the 2-h post-exercise period, chemerin decreased to 12% below baseline, compared to a 2.5% increase above baseline during that time period on the sedentary day (p=0.06, difference in post-to-2h change between conditions). Controlling for homeostatic model assessment of insulin resistance (HOMA-IR), a significant difference existed between EX and SED in the change in chemerin from baseline to 2-h post (p=0.02). Stratified analyses showed a consistent exercise-induced decrease in chemerin among non-insulin resistant subjects, while chemerin increased during exercise among insulin resistant subjects, and then decreased post-exercise. CONCLUSION: An acute bout of exercise in obese individuals may elicit a drop in chemerin levels during the post-exercise period, and this response may vary based on insulin resistance.
Authors: John P Chamberland; Reena L Berman; Konstantinos N Aronis; Christos S Mantzoros Journal: Eur J Endocrinol Date: 2013-09-13 Impact factor: 6.664