Javier Rueda-Gotor1, Alfonso Corrales1, Ricardo Blanco1, Patricia Fuentevilla1, Virginia Portilla1, Rosa Expósito2, Cristina Mata2, Trinitario Pina1, Carlos González-Juanatey3, Javier Llorca4, Miguel A González-Gay5. 1. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain. 2. Division of Rheumatology, Hospital Comarcal, Laredo, Cantabria, Spain. 3. Division of Cardiology, Hospital Lucus Augusti, Lugo, Spain. 4. Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, and CIBER Epidemiología y Salud Pública (CIBERESP), Spain. 5. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, and Cardiovascular Pathophysiology and Genomics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Abstract
OBJECTIVES: To establish whether subclinical atherosclerosis is increased in patients with axial spondyloarthritis (ax-SpA). METHODS: A set of 149 consecutive patients with no history of cardiovascular disease that fulfilled the Assessment of SpondyloArthritis International Society classification criteria for ax-SpA was studied by carotid ultrasonography. Carotid intima-media thickness (cIMT) and plaques were assessed. A series of 181 community-based controls with no cardiovascular disease were studied for comparison. To establish whether ax-SpA might have a direct effect on the risk of carotid plaques or an indirect effect via its putative influence on hypertension, dyslipidaemia or obesity, we obtained adjusted odds ratios (OR) for each clinical factor by the development of adjusted models. RESULTS: cIMT was increased in patients (0.621±0.123 mm) when compared to controls (0.607±0.117 mm) but the difference was not significant (p=0.30). Nevertheless, carotid plaques were more commonly observed in patients with ax-SpA than in controls (41.6% vs. 26.4%; p=0.003). Patients with plaques had longer duration of the disease than those without plaques (20.5±11.2 years vs. 12.0±8.6 years; p<0.001). Plaques were more frequent in patients with hip involvement (crude odds ratio 3.15, 95% confidence interval [CI] 1.02-9.75; p=0.05), syndesmophytes (crude OR 4.94, 95% CI 2.14-11.4; p<0.001), in patients with higher functional limitation and mobility index measured by BASFI (crude OR 1.16, 95% CI 1.02-1.33; p=0.03) and BASMI (crude OR 1.45, 95% CI 1.19-1.77; p<0.001), and in those with psoriasis (crude OR 3.94, 95% CI 1.31-11.84; p=0.02. However, except for psoriasis that continued being a strong risk factor for plaques after adjustment, the relationship between other clinical features of ax-SpA and carotid plaques disappeared in the adjusted models. CONCLUSIONS: Our results confirm the presence of subclinical atherosclerosis in patients with ax-SpA.
OBJECTIVES: To establish whether subclinical atherosclerosis is increased in patients with axial spondyloarthritis (ax-SpA). METHODS: A set of 149 consecutive patients with no history of cardiovascular disease that fulfilled the Assessment of SpondyloArthritis International Society classification criteria for ax-SpA was studied by carotid ultrasonography. Carotid intima-media thickness (cIMT) and plaques were assessed. A series of 181 community-based controls with no cardiovascular disease were studied for comparison. To establish whether ax-SpA might have a direct effect on the risk of carotid plaques or an indirect effect via its putative influence on hypertension, dyslipidaemia or obesity, we obtained adjusted odds ratios (OR) for each clinical factor by the development of adjusted models. RESULTS: cIMT was increased in patients (0.621±0.123 mm) when compared to controls (0.607±0.117 mm) but the difference was not significant (p=0.30). Nevertheless, carotid plaques were more commonly observed in patients with ax-SpA than in controls (41.6% vs. 26.4%; p=0.003). Patients with plaques had longer duration of the disease than those without plaques (20.5±11.2 years vs. 12.0±8.6 years; p<0.001). Plaques were more frequent in patients with hip involvement (crude odds ratio 3.15, 95% confidence interval [CI] 1.02-9.75; p=0.05), syndesmophytes (crude OR 4.94, 95% CI 2.14-11.4; p<0.001), in patients with higher functional limitation and mobility index measured by BASFI (crude OR 1.16, 95% CI 1.02-1.33; p=0.03) and BASMI (crude OR 1.45, 95% CI 1.19-1.77; p<0.001), and in those with psoriasis (crude OR 3.94, 95% CI 1.31-11.84; p=0.02. However, except for psoriasis that continued being a strong risk factor for plaques after adjustment, the relationship between other clinical features of ax-SpA and carotid plaques disappeared in the adjusted models. CONCLUSIONS: Our results confirm the presence of subclinical atherosclerosis in patients with ax-SpA.
Authors: Fernanda Genre; Raquel López-Mejías; José A Miranda-Filloy; Begoña Ubilla; Verónica Mijares; Beatriz Carnero-López; Inés Gómez-Acebo; Trinidad Dierssen-Sotos; Sara Remuzgo-Martínez; Ricardo Blanco; Trinitario Pina; Carlos González-Juanatey; Javier Llorca; Miguel A González-Gay Journal: Rheumatol Int Date: 2015-07-05 Impact factor: 2.631
Authors: Javier Rueda-Gotor; Fernanda Genre; Alfonso Corrales; Ricardo Blanco; Patricia Fuentevilla; Virginia Portilla; Rosa Expósito; Cristina Mata Arnaiz; Trinitario Pina; Carlos González-Juanatey; Luis Rodriguez-Rodriguez; Miguel A González-Gay Journal: Int J Rheumatol Date: 2018-02-15
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Authors: Javier Rueda-Gotor; Fernanda Genre; Alfonso Corrales; Ricardo Blanco; Patricia Fuentevilla; Virginia Portilla; Rosa Expósito; Cristina Mata; Trinitario Pina; Carlos González-Juanatey; Luis Rodriguez-Rodriguez; Miguel A González-Gay Journal: Arthritis Res Ther Date: 2018-08-29 Impact factor: 5.156
Authors: Fernanda Genre; Javier Rueda-Gotor; Sara Remuzgo-Martínez; Verónica Pulito-Cueto; Alfonso Corrales; Verónica Mijares; Leticia Lera-Gómez; Virginia Portilla; Rosa Expósito; Cristina Mata; Ricardo Blanco; Javier Llorca; Vanesa Hernández-Hernández; Esther Vicente; Cristina Fernández-Carballido; María Paz Martínez-Vidal; David Castro-Corredor; Joaquín Anino-Fernández; Carlos Rodríguez-Lozano; Oreste Gualillo; Juan Carlos Quevedo-Abeledo; Santos Castañeda; Iván Ferraz-Amaro; Raquel López-Mejías; Miguel Á González-Gay Journal: Sci Rep Date: 2020-06-15 Impact factor: 4.379