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Literature DB >> 26005707

Regulating Tumor Myeloid-Derived Suppressor Cells by MicroRNAs.

Siqi Chen¹, Yi Zhang², Timothy M Kuzel³, Bin Zhang¹.

Abstract

Myeloid-derived suppressor cells (MDSCs) are one of the major cell components responsible for cancer immune evasion. Studying mechanisms associated with the regulation of MDSCs is becoming appreciated as another way to manipulate immune responses. MicroRNAs (miRNAs) have been recognized as substances which may interact with MDSCs, and eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function. We have reviewed the data supporting this activity of these entities.

Entities: CellLine Chemical Disease Gene Species

Keywords: MDSC; immunosuppression; immunotherapy; microRNA; tumor microenvironment

Year: 2015 PMID： 26005707 PMCID： PMC4440580 DOI： 10.14800/ccm.637

Source DB: PubMed Journal: Cancer Cell Microenviron

39 in total

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Journal: Nat Rev Genet Date: 2004-07 Impact factor: 53.242

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Journal: Adv Exp Med Biol Date: 2011 Impact factor: 2.622

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Authors: Mohamed El Gazzar; Charles E McCall
Journal: Immunol Cell Biol Date: 2011-09-13 Impact factor: 5.126

Review 4. Immunosuppressive networks in the tumour environment and their therapeutic relevance.

Authors: Weiping Zou
Journal: Nat Rev Cancer Date: 2005-04 Impact factor: 60.716

5. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent.

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Journal: Cancer Res Date: 2005-04-15 Impact factor: 12.701

6. Host miR155 promotes tumor growth through a myeloid-derived suppressor cell-dependent mechanism.

Authors: Siqi Chen; Long Wang; Jie Fan; Cong Ye; Donye Dominguez; Yi Zhang; Tyler J Curiel; Deyu Fang; Timothy M Kuzel; Bin Zhang
Journal: Cancer Res Date: 2014-12-10 Impact factor: 12.701

Review 7. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity.

Authors: Je-In Youn; Dmitry I Gabrilovich
Journal: Eur J Immunol Date: 2010-11 Impact factor: 5.532

Review 8. Myeloid-derived suppressor cell heterogeneity in human cancers.

Authors: Samantha Solito; Ilaria Marigo; Laura Pinton; Vera Damuzzo; Susanna Mandruzzato; Vincenzo Bronte
Journal: Ann N Y Acad Sci Date: 2014-06 Impact factor: 5.691

9. Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.

Authors: Thomas B Huffaker; Ruozhen Hu; Marah C Runtsch; Erin Bake; Xinjian Chen; Jimmy Zhao; June L Round; David Baltimore; Ryan M O'Connell
Journal: Cell Rep Date: 2012-11-29 Impact factor: 9.423

10. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice.

Authors: Maciej Kujawski; Marcin Kortylewski; Heehyoung Lee; Andreas Herrmann; Heidi Kay; Hua Yu
Journal: J Clin Invest Date: 2008-10 Impact factor: 14.808

24 in total

1. Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions.

Authors: Lucía Geis-Asteggiante; Ashton T Belew; Virginia K Clements; Nathan J Edwards; Suzanne Ostrand-Rosenberg; Najib M El-Sayed; Catherine Fenselau
Journal: J Proteome Res Date: 2017-11-27 Impact factor: 4.466

Review 2. Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.

Authors: Peng Qu; Li-Zhen Wang; P Charles Lin
Journal: Cancer Lett Date: 2015-10-28 Impact factor: 8.679

3. Langerhans, plasmacytoid dendritic and myeloid-derived suppressor cell levels in mycosis fungoides vary according to the stage of the disease.

Authors: Alessandro Pileri; Claudio Agostinelli; Maurizio Sessa; Pietro Quaglino; Marco Santucci; Carlo Tomasini; Vieri Grandi; Paolo Fava; Chiara Astrua; Simona Righi; Annalisa Patrizi; Stefano A Pileri; Nicola Pimpinelli
Journal: Virchows Arch Date: 2017-03-20 Impact factor: 4.064

Review 4. Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment.

Authors: Zijie Xu; Yi Chen; Ling Ma; Yizhang Chen; Jingya Liu; Yuchen Guo; Ting Yu; Lianghui Zhang; Lingjun Zhu; Yongqian Shu
Journal: Mol Ther Date: 2022-04-09 Impact factor: 12.910

Review 5. The immunobiology of myeloid-derived suppressor cells in cancer.

Authors: Morteza Motallebnezhad; Farhad Jadidi-Niaragh; Elmira Safaie Qamsari; Salman Bagheri; Tohid Gharibi; Mehdi Yousefi
Journal: Tumour Biol Date: 2015-11-26

6. AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes.

Authors: Wurood Hantoosh Neamah; Narendra P Singh; Hasan Alghetaa; Osama A Abdulla; Saurabh Chatterjee; Philip B Busbee; Mitzi Nagarkatti; Prakash Nagarkatti
Journal: J Immunol Date: 2019-09-06 Impact factor: 5.422

7. MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65.

Authors: Shouhe Yu; Qianqian Geng; Qiuhui Pan; Zhongyu Liu; Shan Ding; Qi Xiang; Fenyong Sun; Can Wang; Yadong Huang; An Hong
Journal: Cell Biosci Date: 2016-02-12 Impact factor: 7.133