How B cells remember? A sophisticated cytoplasmic tail of mIgG is pivotal for the enhanced transmembrane signaling of IgG-switched memory B cells.

Antibody memory is critical for protection against many human infectious diseases and is the basis for nearly all current human vaccines. Isotype switched immunoglobulin (Ig) G-expressing memory B cells are considered as one of the fundaments for the rapid, high affinity and high-titered memory antibody response. The detailed molecular mechanism of the enhanced activation of IgG-switched memory B cells upon BCR engagement with antigens has been an elusive question in immunology. In this review, we tried to discuss all the exciting new advances revealing the molecular mechanisms of the transmembrane signaling through mIgG cytoplasmic tail in IgG-switched memory B cells.