Literature DB >> 26004751

The influence of fluorine position on the properties of fluorobenzoxaboroles.

Agnieszka Adamczyk-Woźniak1, Małgorzata K Cabaj2, Paulina M Dominiak2, Patrycja Gajowiec1, Błażej Gierczyk3, Jacek Lipok4, Łukasz Popenda5, Grzegorz Schroeder3, Ewelina Tomecka1, Piotr Urbański1, Dorota Wieczorek4, Andrzej Sporzyński6.   

Abstract

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antifungal activity; Benzoxaboroles; Crystal structure; Tavaborole

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Substances：

Year:  2015        PMID： 26004751     DOI： 10.1016/j.bioorg.2015.05.004

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  4 in total

Review 1.  Reactive chemistry for covalent probe and therapeutic development.

Authors:  R Justin Grams; Ku-Lung Hsu
Journal:  Trends Pharmacol Sci       Date:  2022-01-06       Impact factor: 14.819

Review 2.  Merging Electron Deficient Boronic Centers with Electron-Withdrawing Fluorine Substituents Results in Unique Properties of Fluorinated Phenylboronic Compounds.

Authors:  Agnieszka Adamczyk-Woźniak; Andrzej Sporzyński
Journal:  Molecules       Date:  2022-05-26       Impact factor: 4.927

3.  Mechanochemical synthesis of antifungal bis(benzoxaboroles).

Authors:  Krzysztof M Borys; Dorota Wieczorek; Magdalena Tarkowska; Agnieszka Jankowska; Jacek Lipok; Agnieszka Adamczyk-Woźniak
Journal:  RSC Adv       Date:  2020-10-07       Impact factor: 4.036

4.  Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology - phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells.

Authors:  Mateusz Psurski; Agnieszka Łupicka-Słowik; Agnieszka Adamczyk-Woźniak; Joanna Wietrzyk; Andrzej Sporzyński
Journal:  Invest New Drugs       Date:  2018-05-19       Impact factor: 3.850
  4 in total

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