Danielle A Baribeau1, Krissy A R Doyle-Thomas2, Annie Dupuis3, Alana Iaboni2, Jennifer Crosbie3, Holly McGinn4, Paul D Arnold3, Jessica Brian5, Azadeh Kushki6, Rob Nicolson7, Russell J Schachar3, Noam Soreni8, Peter Szatmari9, Evdokia Anagnostou10. 1. University of Toronto. 2. Bloorview Research Institute, Toronto. 3. The Hospital for Sick Children and the University of Toronto. 4. The Hospital for Sick Children, Toronto. 5. Bloorview Research Institute and the University of Toronto. 6. Bloorview Research Institute and the Institute of Biomaterials and Biomedical Engineering, University of Toronto. 7. Children's Health Research Institute and Western University, London, Ontario, Canada. 8. McMaster University, Hamilton, Ontario, Canada. 9. The Hospital for Sick Children, the Centre for Addiction and Mental Health, Toronto, and the University of Toronto. 10. Bloorview Research Institute and the University of Toronto. Electronic address: eanagnostou@hollandbloorview.ca.
Abstract
OBJECTIVE: Several neurodevelopmental disorders are associated with social processing deficits. The objective of this study was to compare patterns of social perception abilities across obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and control participants. METHOD: A total of 265 children completed the Reading the Mind in the Eyes Test-Child Version (RMET). Parents or caregivers completed established trait/symptom scales. The predicted percentage of accuracy on the RMET was compared across disorders and by item difficulty and item valence (i.e., positive/negative/neutral mental states), then analyzed for associations with trait/symptom scores. RESULTS: The percentage of correct RMET scores varied significantly between diagnostic groups (p < .0001). On pairwise group comparisons controlling for age and sex, children with ADHD and ASD scored lower than the other groups (p < .0001). When IQ was also controlled for in the model, participants with OCD performed better than controls (p < .001), although differences between other groups were less pronounced. Participants with ASD scored lowest on easy items. Those with ASD and ADHD scored significantly lower than other groups on items with positive valence (p < .01). Greater social communication impairment and hyperactivity/impulsivity, but not OCD traits/symptoms, were associated with lower scores on the RMET, irrespective of diagnosis. CONCLUSION: Social perception abilities in neurodevelopmental disorders exist along a continuum. Children with ASD have the greatest deficits, whereas children with OCD may be hypersensitive to social information. Social communication deficits and hyperactive/impulsive traits are associated with impaired social perception abilities; these findings highlight overlapping cognitive and behavioral manifestations across disorders.
OBJECTIVE: Several neurodevelopmental disorders are associated with social processing deficits. The objective of this study was to compare patterns of social perception abilities across obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and control participants. METHOD: A total of 265 children completed the Reading the Mind in the Eyes Test-Child Version (RMET). Parents or caregivers completed established trait/symptom scales. The predicted percentage of accuracy on the RMET was compared across disorders and by item difficulty and item valence (i.e., positive/negative/neutral mental states), then analyzed for associations with trait/symptom scores. RESULTS: The percentage of correct RMET scores varied significantly between diagnostic groups (p < .0001). On pairwise group comparisons controlling for age and sex, children with ADHD and ASD scored lower than the other groups (p < .0001). When IQ was also controlled for in the model, participants with OCD performed better than controls (p < .001), although differences between other groups were less pronounced. Participants with ASD scored lowest on easy items. Those with ASD and ADHD scored significantly lower than other groups on items with positive valence (p < .01). Greater social communication impairment and hyperactivity/impulsivity, but not OCD traits/symptoms, were associated with lower scores on the RMET, irrespective of diagnosis. CONCLUSION: Social perception abilities in neurodevelopmental disorders exist along a continuum. Children with ASD have the greatest deficits, whereas children with OCD may be hypersensitive to social information. Social communication deficits and hyperactive/impulsive traits are associated with impaired social perception abilities; these findings highlight overlapping cognitive and behavioral manifestations across disorders.
Authors: Marina Charalampopoulou; Eun Jung Choi; Daphne J Korczak; Katherine T Cost; Jennifer Crosbie; Catherine S Birken; Alice Charach; Suneeta Monga; Elizabeth Kelley; Rob Nicolson; Stelios Georgiades; Muhammad Ayub; Russell J Schachar; Alana Iaboni; Evdokia Anagnostou Journal: Paediatr Child Health Date: 2022-09-08 Impact factor: 2.600
Authors: Tomer Levy; Annie Dupuis; Brendan F Andrade; Jennifer Crosbie; Elizabeth Kelley; Rob Nicolson; Russell James Schachar Journal: Eur Child Adolesc Psychiatry Date: 2022-09-01 Impact factor: 5.349
Authors: Grace R Jacobs; Aristotle N Voineskos; Colin Hawco; Laura Stefanik; Natalie J Forde; Erin W Dickie; Meng-Chuan Lai; Peter Szatmari; Russell Schachar; Jennifer Crosbie; Paul D Arnold; Anna Goldenberg; Lauren Erdman; Stephanie H Ameis Journal: Neuropsychopharmacology Date: 2020-11-09 Impact factor: 7.853