Literature DB >> 26004252

Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain.

I Fernandez-Sainz1, P Ramanathan2, V O'Donnell3, F Diaz-San Segundo4, L Velazquez-Salinas5, D F Sturza6, J Zhu7, T de los Santos8, M V Borca9.   

Abstract

Interferon-alpha (IFNα) can effectively inhibit or abort a viral infection within the host. It has been reported that IFN induction and production is hindered during classical swine fever virus (CSFV) infection. Most of those studies have been performed in vitro, making it difficult to elucidate the actual role of IFNs during CSFV infection in swine. Here, we report the effect of IFNα treatment (delivered by a replication defective recombinant human adenovirus type 5, Ad5) in swine experimentally infected with highly virulent CSFV strain Brescia. Treatment with two different subtypes of IFNα delayed the appearance of CSF-related clinical signs and virus replication although it did not prevent lethal disease. This is the first report describing the effect of IFNα treatment during CSFV infection in swine. Published by Elsevier Inc.

Entities:  

Keywords:  Classical swine fever virus; Interferon type I; Protection

Mesh：

Substances：

Year:  2015        PMID： 26004252     DOI： 10.1016/j.virol.2015.04.024

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  10 in total

1.  Peste des Petits Ruminants Virus Exhibits Cell-Dependent Interferon Active Response.

Authors:  Jingyu Tang; Aoxing Tang; Hanyu Du; Nannan Jia; Jie Zhu; Chuanfeng Li; Chunchun Meng; Guangqing Liu
Journal:  Front Cell Infect Microbiol       Date:  2022-05-31       Impact factor: 6.073

2.  Early protection events in swine immunized with an experimental live attenuated classical swine fever marker vaccine, FlagT4G.

Authors:  Lauren G Holinka; Vivian O'Donnell; Guillermo R Risatti; Paul Azzinaro; Jonathan Arzt; Carolina Stenfeldt; Lauro Velazquez-Salinas; Jolene Carlson; Douglas P Gladue; Manuel V Borca
Journal:  PLoS One       Date:  2017-05-24       Impact factor: 3.240

3.  Increased Virulence of an Epidemic Strain of Vesicular Stomatitis Virus Is Associated With Interference of the Innate Response in Pigs.

Authors:  Lauro Velazquez-Salinas; Steven J Pauszek; Carolina Stenfeldt; Emily S O'Hearn; Juan M Pacheco; Manuel V Borca; Antonio Verdugo-Rodriguez; Jonathan Arzt; Luis L Rodriguez
Journal:  Front Microbiol       Date:  2018-08-15       Impact factor: 5.640

4.  Head Start Immunity: Characterizing the Early Protection of C Strain Vaccine Against Subsequent Classical Swine Fever Virus Infection.

Authors:  Ronan R McCarthy; Helen E Everett; Simon P Graham; Falko Steinbach; Helen R Crooke
Journal:  Front Immunol       Date:  2019-07-23       Impact factor: 7.561

5.  Maternally-derived neutralizing antibodies reduce vaccine efficacy against porcine reproductive and respiratory syndrome virus infection.

Authors:  Patricia Renson; Christelle Fablet; Mathieu Andraud; Valérie Normand; Arnaud Lebret; Frédéric Paboeuf; Nicolas Rose; Olivier Bourry
Journal:  Vaccine       Date:  2019-06-24       Impact factor: 3.641

6.  Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs.

Authors:  Chandrika Senthilkumaran; Andrea L Kroeker; Gregory Smith; Carissa Embury-Hyatt; Brad Collignon; Elizabeth Ramirez-Medina; Paul A Azzinaro; Bradley S Pickering; Fayna Diaz-San Segundo; Hana M Weingartl; Teresa de Los Santos
Journal:  Pathogens       Date:  2022-04-08

Review 7.  The Development of Classical Swine Fever Marker Vaccines in Recent Years.

Authors:  Fangfang Li; Bingke Li; Xinni Niu; Wenxian Chen; Yuwan Li; Keke Wu; Xiaowen Li; Hongxing Ding; Mingqiu Zhao; Jinding Chen; Lin Yi
Journal:  Vaccines (Basel)       Date:  2022-04-13

8.  Modulation of Type I Interferon System by African Swine Fever Virus.

Authors:  Elisabetta Razzuoli; Giulia Franzoni; Tania Carta; Susanna Zinellu; Massimo Amadori; Paola Modesto; Annalisa Oggiano
Journal:  Pathogens       Date:  2020-05-09

9.  Antiviral activity of ISG15 against classical swine fever virus replication in porcine alveolar macrophages via inhibition of autophagy by ISGylating BECN1.

Authors:  Cheng Li; Yifan Wang; Hongqing Zheng; Wang Dong; Huifang Lv; Jihui Lin; Kangkang Guo; Yanming Zhang
Journal:  Vet Res       Date:  2020-02-24       Impact factor: 3.683

10.  Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide.

Authors:  Giulia Franzoni; Antonio Anfossi; Chiara Grazia De Ciucis; Samanta Mecocci; Tania Carta; Silvia Dei Giudici; Floriana Fruscione; Susanna Zinellu; Guendalina Vito; Simon Paul Graham; Annalisa Oggiano; Bernardo Chessa; Elisabetta Razzuoli
Journal:  Vaccines (Basel)       Date:  2021-06-23
  10 in total

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