| Literature DB >> 26004156 |
Erdinç Dursun1, Duygu Gezen-Ak2, Haşmet Hanağası3, Başar Bilgiç3, Ebba Lohmann3, Sibel Ertan4, İrem L Atasoy5, Merve Alaylıoğlu5, Ömür Selin Araz5, Burak Önal6, Ayşegül Gündüz4, Hülya Apaydın4, Güneş Kızıltan4, Turgut Ulutin5, Hakan Gürvit3, Selma Yılmazer7.
Abstract
Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA. IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls. A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.Entities:
Keywords: Alpha-2 macroglobulin (α2-macroglobulin); Alzheimer's disease; Biomarker; Brain derived neurotrophic factor (BDNF); Heat shock protein 90 (Hsp90); Interleukin 1 alpha (IL-1α); Interleukin 1 beta (IL-1β); Interleukin 10 (IL-10); Interleukin 6 (IL-6); Mild cognitive impairment (MCI); Parkinson's disease (PD); Tumor necrosis factor alpha (TNFα)
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Year: 2015 PMID： 26004156 DOI： 10.1016/j.jneuroim.2015.04.014
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478