| Literature DB >> 26004081 |
Crystal Humphries1, Martin A Kohli2, Patrice Whitehead2, Deborah C Mash3, Margaret A Pericak-Vance1, John Gilbert4.
Abstract
Genome-wide association studies have identified twenty loci associated with late-onset Alzheimer disease (LOAD). We examined each of the twenty loci, specifically the ±50kb region surrounding the most strongly associated variant, for changes in gene(s) transcription specific to LOAD. Post-mortem human brain samples were examined for expression, methylation, and splicing differences. LOAD specific differences were detected by comparing LOAD to normal and "disease" controls. Eight loci, prominently ABCA7, contain LOAD specific differences. Significant changes in the CELF1 and ZCWPW1 loci occurred in genes not located nearest the associated variant, suggesting that these genes should be investigated further as LOAD candidates.Entities:
Keywords: DNA methylation; Dementia with Lewy bodies; Differential expression; Genome-wide association study; Late-onset Alzheimer disease; Microarray; RNA-Seq; Splicing; Transcription
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Year: 2015 PMID： 26004081 PMCID： PMC4540636 DOI： 10.1016/j.mcn.2015.05.003
Source DB: PubMed Journal: Mol Cell Neurosci ISSN： 1044-7431 Impact factor: 4.314