Literature DB >> 26003627

The occurrence of auditory dysfunction in children with TB receiving ototoxic medication at a TB hospital in South Africa.

Nazanin Ghafari1, Christine Rogers2, Lucretia Petersen3, Shajila A Singh4.   

Abstract

OBJECTIVES: to describe the auditory dysfunction of children with tuberculosis receiving ototoxic medication at a residential TB hospital in the Cape Town metropolitan area.
METHODS: A descriptive survey research design was adopted. The auditory status of participants was evaluated by otoscopy, immittance, audiometry or OAE and AABR (depending on the age). STUDY SAMPLE: 29 in-patients (7 months to 16.6 years).
RESULTS: Fifty five percent of participants presented with middle ear abnormalities (n=16) and 48% (n=12) had sensorineural or mixed hearing loss. The degree of hearing loss ranged from mild to profound in 16% of the ears. The conventional pure-tone average of .5, 1, & 2 kHz did not allow for the determination of the degree of hearing loss in the remaining 18% which had high frequency hearing loss.
CONCLUSIONS: The high occurrence of hearing loss necessitates the implementation of monitoring program for children receiving ototoxic medication. Consideration should be given to using the average of hearing thresholds at 4, 6 and 8 kHz to determine the classification of degree of hearing loss in cases of ototoxicity.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Children; Hearing loss; Monitoring; Ototoxicity; TB

Mesh:

Substances:

Year:  2015        PMID: 26003627     DOI: 10.1016/j.ijporl.2015.04.040

Source DB:  PubMed          Journal:  Int J Pediatr Otorhinolaryngol        ISSN: 0165-5876            Impact factor:   1.675


  4 in total

1.  Pharmacokinetics and other risk factors for kanamycin-induced hearing loss in patients with multi-drug resistant tuberculosis.

Authors:  Nazanin Ghafari; Richard Court; Maxwell Tawanda Chirehwa; Lubbe Wiesner; Lucretia Petersen; Gary Maartens; Tawanda Gumbo; Helen McIlleron; Lebogang Ramma
Journal:  Int J Audiol       Date:  2019-11-18       Impact factor: 2.117

2.  Challenge to treat pre-extensively drug-resistant tuberculosis in a low-income country: A report of 12 cases.

Authors:  Innocent Murhula Kashongwe; Fina Mawete; Nicole Anshambi; Nadine Maingowa; Murielle Aloni; Luc Lukaso L'osenga; Michel Kaswa; Zacharie Munogolo Kashongwe
Journal:  J Clin Tuberc Other Mycobact Dis       Date:  2020-09-22

3.  Tuberculosis related disability: a systematic review and meta-analysis.

Authors:  Kefyalew Addis Alene; Kinley Wangdi; Samantha Colquhoun; Kudakwashe Chani; Tauhid Islam; Kalpeshsinh Rahevar; Fukushi Morishita; Anthony Byrne; Justin Clark; Kerri Viney
Journal:  BMC Med       Date:  2021-09-09       Impact factor: 8.775

Review 4.  Ototoxicity: A review of South African studies.

Authors:  Selvarani Moodley; Claudine Storbeck; Nomthandazo Gama
Journal:  S Afr Fam Pract (2004)       Date:  2021-03-15
  4 in total

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