| Literature DB >> 26003528 |
Vladan Bajic1, Biljana Spremo-Potparevic2, Lada Zivkovic3, Esma R Isenovic4, Thomas Arendt5.
Abstract
Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD.Entities:
Keywords: Alzheimer's disease (AD); Aneuploidy; Cell cycle; Cohesion; Genomic mosaicism
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Year: 2015 PMID： 26003528 DOI： 10.1016/j.neubiorev.2015.05.010
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989