Elisa J Gordon1, Jillian Rodde2, Anton Skaro3, Talia Baker3. 1. Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States. Electronic address: e-gordon@northwestern.edu. 2. Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States. 3. Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Abstract
BACKGROUND & AIMS: Adult-to-adult live donor liver transplantation (LDLT) poses serious health risks and no direct health benefits to donors. Ensuring live donors' autonomy through informed consent is critical. We assessed live liver donors' (LD) comprehension, information needs, risk perceptions, and demographics. METHODS: Semi-structured interviews were prospectively conducted with LDs after completing donor evaluation and informed consent at our transplant center. Likert scales measured informed consent domains. Open-ended responses underwent thematic analysis. RESULTS: Thirty LDs participated (100% participation rate). Although 90% of LDs reported being informed about donation 'a great deal', only 66% reported understanding information about donation 'a great deal.' Many (40%) reported difficulty understanding medical terminology. Information LDs most desired to feel comfortable with their decision included: incidence and type of donor complications (67%), description of donation procedure (57%), and the process of donor preparation (43%). Most (83%) LDs rated risks to themselves as 'not at all' to 'somewhat' risky, and minimized these risks. CONCLUSIONS: Although LDs perceived that they were adequately informed, their actual comprehension about donation was inadequate. Findings suggest the value of informed consent for preparation for the procedure and potential periprocedural risks rather than for decision-making. More comprehensible information disclosure may optimize informed consent.
BACKGROUND & AIMS: Adult-to-adult live donor liver transplantation (LDLT) poses serious health risks and no direct health benefits to donors. Ensuring live donors' autonomy through informed consent is critical. We assessed live liver donors' (LD) comprehension, information needs, risk perceptions, and demographics. METHODS: Semi-structured interviews were prospectively conducted with LDs after completing donor evaluation and informed consent at our transplant center. Likert scales measured informed consent domains. Open-ended responses underwent thematic analysis. RESULTS: Thirty LDs participated (100% participation rate). Although 90% of LDs reported being informed about donation 'a great deal', only 66% reported understanding information about donation 'a great deal.' Many (40%) reported difficulty understanding medical terminology. Information LDs most desired to feel comfortable with their decision included: incidence and type of donor complications (67%), description of donation procedure (57%), and the process of donor preparation (43%). Most (83%) LDs rated risks to themselves as 'not at all' to 'somewhat' risky, and minimized these risks. CONCLUSIONS: Although LDs perceived that they were adequately informed, their actual comprehension about donation was inadequate. Findings suggest the value of informed consent for preparation for the procedure and potential periprocedural risks rather than for decision-making. More comprehensible information disclosure may optimize informed consent.
Authors: Muhammad H Raza; Whitney E Jackson; Angela Dell; Li Ding; James Shapiro; Elizabeth A Pomfret; Yuri Genyk; Linda Sher; Juliet Emamaullee Journal: Am J Transplant Date: 2020-09-03 Impact factor: 8.086
Authors: Emerentia Q W Spoon; Kirsten Kortram; Sohal Y Ismail; Daan Nieboer; Frank C H d'Ancona; Maarten H L Christiaans; Ruth E Dam; Hendrik Sijbrand Hofker; Arjan W J Hoksbergen; Karlijn Ami van der Pant; Raechel J Toorop; Jacqueline van de Wetering; Jan N M Ijzermans; Frank J M F Dor Journal: J Clin Med Date: 2022-01-28 Impact factor: 4.241
Authors: Kirsten Kortram; Emerentia Q W Spoon; Sohal Y Ismail; Frank C H d'Ancona; Maarten H L Christiaans; L W Ernest van Heurn; H Sijbrand Hofker; Arjan W J Hoksbergen; Jaap J Homan van der Heide; Mirza M Idu; Caspar W N Looman; S Azam Nurmohamed; Jan Ringers; Raechel J Toorop; Jacqueline van de Wetering; Jan N M Ijzermans; Frank J M F Dor Journal: BMJ Open Date: 2016-04-01 Impact factor: 2.692