Literature DB >> 26002945

Steroid-induced glaucoma and childhood blindness.

Shikha Gupta1, Pooja Shah1, Sartaj Grewal1, Abadh Kishore Chaurasia1, Viney Gupta1.   

Abstract

AIM: To determine the prevalence, risk factors and the severity of visual loss caused by steroid-induced glaucoma (SIG) among children.
METHODS: Five-year records of all paediatric glaucoma cases presenting to the glaucoma services of our tertiary care centre were evaluated. Data of children presenting with SIG were recorded with respect to their visual acuity, highest baseline intraocular pressure, cup:disc ratio, perimetry and need of glaucoma filtering surgery. Parents were interviewed to assess the indication of steroid use, type of steroid used, person prescribing it and the duration of use. The prevalence of visual impairment was calculated based on WHO criteria.
RESULTS: Of 1259 cases of paediatric glaucoma presenting at our centre over 5 years, 59 children (4.7%) were diagnosed with SIG. Of these, 51 (87%) had been prescribed topical steroids for vernal keratoconjunctivitis (VKC). The median duration of steroid use was 18 months (range 1 month to 8 years). Also, 82% of children with VKC had been prescribed steroids by the treating ophthalmologist and 52% had been on topical steroids for >1 year. Glaucomatous optic neuropathy was the cause of blindness in 37.3% (22/59) and low vision in 23.7% (14/59) children. And 27% (16/59) were unilaterally blind at presentation.
CONCLUSIONS: A third of the children presenting with SIG to our tertiary care centre were bilaterally blind at presentation. Ophthalmologists need to consider steroid-sparing agents to treat VKC and monitor these children closely for glaucoma if they prescribe topical steroids in order to prevent unnecessary childhood blindness. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Entities:  

Keywords:  Field of vision; Glaucoma; Intraocular pressure; Optic Nerve; Vision

Mesh:

Substances:

Year:  2015        PMID: 26002945     DOI: 10.1136/bjophthalmol-2014-306557

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  9 in total

1.  Steroid-induced protracted severe ocular hypertension in a 14-year-old girl.

Authors:  David Cordeiro Sousa; Inês Leal; Luis Abegão Pinto
Journal:  BMJ Case Rep       Date:  2018-06-27

2.  The short-term effects of intranasal steroids on intraocular pressure in pediatric population.

Authors:  Taylan Ozturk; Ceren Durmaz Engin; Seher Koksaldi; Gul Arikan
Journal:  Int Ophthalmol       Date:  2022-07-12       Impact factor: 2.029

3.  Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial.

Authors:  Minjie Chen; Bilian Ke; Jun Zou; Lan Gong; Yan Wang; Chaoran Zhang; Jianjiang Xu; Anji Wei; Jiaxu Hong
Journal:  J Clin Med       Date:  2022-07-04       Impact factor: 4.964

4.  Reciprocal Regulation between lncRNA ANRIL and p15 in Steroid-Induced Glaucoma.

Authors:  Peixing Wan; Siyu Huang; Yanting Luo; Caibin Deng; Jiajian Zhou; Erping Long; Yehong Zhuo
Journal:  Cells       Date:  2022-04-27       Impact factor: 7.666

Review 5.  Steroid-induced Glaucoma: An Avoidable Irreversible Blindness.

Authors:  Sonia Phulke; Sushmita Kaushik; Savleen Kaur; S S Pandav
Journal:  J Curr Glaucoma Pract       Date:  2017-08-05

6.  Long-term outcomes and risk factors for failure of glaucoma filtering surgery in eyes with vernal keratoconjunctivitis and steroid-induced glaucoma.

Authors:  Sirisha Senthil; Harsha L Rao; Mohammed Hasnat Ali; Rashmi Krishnamurthy; Siddharth Dikshit; Nikhil Choudhari; Ramyasri Sastry; Chandrashekar Garudadri
Journal:  Indian J Ophthalmol       Date:  2022-03       Impact factor: 2.969

7.  Severe Corticosteroid-Induced Ocular Hypertension Requiring Bilateral Trabeculectomies in a Patient with Takayasu's Arteritis.

Authors:  Anna Maria Gruener; Pranev Sharma; Sally Ameen; Faisal Ahmed
Journal:  Case Rep Ophthalmol Med       Date:  2016-11-10

8.  Commentary: Blindness from glaucoma associated with steroid abuse in children.

Authors:  R Krishnadas
Journal:  Indian J Ophthalmol       Date:  2019-10       Impact factor: 1.848

9.  Pattern of steroid misuse in vernal keratoconjunctivitis resulting in steroid induced glaucoma and visual disability in Indian rural population: An important public health problem in pediatric age group.

Authors:  Pradhnya Sen; Swapnil Jain; Amit Mohan; Chintan Shah; Alok Sen; Elesh Jain
Journal:  Indian J Ophthalmol       Date:  2019-10       Impact factor: 1.848

  9 in total

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