Ming-Huang Chen1, Ying-Ju Kuo2, Yi-Chen Yeh2, Ying-Chu Lin3, Cheng-Hwai Tzeng1, Chun-Yu Liu1, Peter Mu-Hsin Chang1, Ming-Han Chen4, Yung-Ming Jeng5, Yee Chao6. 1. Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. 2. Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. 3. Division of Hematology and Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. 4. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. 5. Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC. 6. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. Electronic address: ychao@vghtpe.gov.tw.
Abstract
BACKGROUND: High-grade malignant mixed adenoneuroendocrine carcinoma (MANEC) is a highly malignant combined neoplasm formed by an adenocarcinomatous component and a poorly differentiated (Grade 3) neuroendocrine (NE) carcinoma. METHODS: Tumors from 21 patients with gastrointestinal high-grade malignant MANECs or tumors with varying percentages of Grade 3 NE component were examined, and the NE component was confirmed by morphological analysis and immunohistochemical staining. Patients were divided into high NE (NE component > 50% in the primary tumor) and low NE (NE component ≤ 50% in the primary tumor) component groups. RESULTS: High NE component was a poor prognostic factor for patients with high grade MANEC (p = 0.021). Out of 13 patients with high-grade malignant MANEC, eight had a pure NE component, one had a pure adenocarcinomatous component, and four had mixed-type cancer in the metastatic lymph nodes. We further enrolled eight patients who had a Grade 3 NE component in the primary tumor and found that the pure NE component in tumor emboli and distant liver metastases were more frequent in the high NE than in the low NE component group (p = 0.012 and p = 0.046, respectively). CONCLUSION: The predominant tumor component in primary tumors was a prognostic factor and could predict tumor emboli and liver metastases pathology in high-grade malignant MANECs.
BACKGROUND: High-grade malignant mixed adenoneuroendocrine carcinoma (MANEC) is a highly malignant combined neoplasm formed by an adenocarcinomatous component and a poorly differentiated (Grade 3) neuroendocrine (NE) carcinoma. METHODS:Tumors from 21 patients with gastrointestinal high-grade malignant MANECs or tumors with varying percentages of Grade 3 NE component were examined, and the NE component was confirmed by morphological analysis and immunohistochemical staining. Patients were divided into high NE (NE component > 50% in the primary tumor) and low NE (NE component ≤ 50% in the primary tumor) component groups. RESULTS: High NE component was a poor prognostic factor for patients with high grade MANEC (p = 0.021). Out of 13 patients with high-grade malignant MANEC, eight had a pure NE component, one had a pure adenocarcinomatous component, and four had mixed-type cancer in the metastatic lymph nodes. We further enrolled eight patients who had a Grade 3 NE component in the primary tumor and found that the pure NE component in tumor emboli and distant liver metastases were more frequent in the high NE than in the low NE component group (p = 0.012 and p = 0.046, respectively). CONCLUSION: The predominant tumor component in primary tumors was a prognostic factor and could predict tumor emboli and liver metastases pathology in high-grade malignant MANECs.
Authors: Zakaria El Barkaoui; Mohammed Najih; Aboulfeth El Mehdi; Hicham El Majdoubi; Imane El Messaoudi; Mohamed Amine Essaoudi; Mohamed Bouzroud; Sidi Mohammed Bouchentouf; Hakim El Kaoui; Ahmed Bounaim Journal: Pan Afr Med J Date: 2021-12-21
Authors: Melissa Frizziero; Xin Wang; Bipasha Chakrabarty; Alexa Childs; Tu V Luong; Thomas Walter; Mohid S Khan; Meleri Morgan; Adam Christian; Mona Elshafie; Tahir Shah; Annamaria Minicozzi; Wasat Mansoor; Tim Meyer; Angela Lamarca; Richard A Hubner; Juan W Valle; Mairéad G McNamara Journal: World J Gastroenterol Date: 2019-10-21 Impact factor: 5.742
Authors: Panpan Zhang; Zhongwu Li; Jie Li; Jian Li; Xiaotian Zhang; Zhihao Lu; Yu Sun; Yan Li; Jun Zhou; Xicheng Wang; Zhi Peng; Lin Shen; Ming Lu Journal: Cancer Med Date: 2021-06-10 Impact factor: 4.452